{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:25:12Z","timestamp":1784762712489,"version":"3.55.0"},"reference-count":24,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"unspecified","delay-in-days":47,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Trauma Surg Acute Care Open"],"accepted":{"date-parts":[[2025,6,6]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Treatment of blunt traumatic spinal cord injuries (SCIs) often includes maintaining elevated mean arterial blood pressures (MAP) to enhance perfusion to the spinal cord. Optimal hyperperfusion protocols and treatment algorithms have yet to be delineated due to a paucity of large volume prospective studies. This study aims to identify predictors of neurological improvement in American Spinal Injury Association (ASIA) impairment score following blunt SCI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study design<\/jats:title>\n                  <jats:p>Prospective (January 10, 2021 to June 1, 2023) multicenter study included blunt SCI patients age &gt;18 with complete neurological examination documented on hospital arrival. Patients were divided into two groups: neurological improvement and no improvement, based on their change in ASIA score from arrival to hospital discharge.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 19 centers contributed 222 patients of those, 164 had pre-ASIA and post-ASIA scores. The ASIA improvement group had 36 patients (22%). There was no statistical difference in the median percentage of time patients spent at a MAP &gt;85\u2009mm Hg during treatment 80.7% (IQR 63.6, 93.4) no improvement vs 83.6% (IQR 70.1, 93.0) in the improvement, (p=0.87). There was no difference in the median duration of MAP treatment in hours between the groups (95.6 hours (IQR 62.55, 113.48) in the no improvement group versus 96 (IQR 72, 113.5) (p=0.40) in the improvement group).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Overall, 22% of all blunt SCI patients saw an improvement in their ASIA score. Adherence to and length of MAP augmentation was not a statistically significantly different between groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Level of evidence<\/jats:title>\n                  <jats:p>Level IV Therapeutic\/Care Management.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/tsaco-2025-001768","type":"journal-article","created":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T22:25:17Z","timestamp":1755469517000},"page":"e001768","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Does mean arterial pressure augmentation improve neurological recovery of blunt spinal cord injuries: an EAST multicenter trial"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7663-4734","authenticated-orcid":false,"given":"Aimee","family":"LaRiccia","sequence":"first","affiliation":[{"name":"OhioHealth, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Doris","sequence":"additional","affiliation":[{"name":"OhioHealth, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhairav","family":"Shah","sequence":"additional","affiliation":[{"name":"OhioHealth, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanisha","family":"Kashikar","sequence":"additional","affiliation":[{"name":"OhioHealth, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Teicher","sequence":"additional","affiliation":[{"name":"Surgery, Inova Fairfax Medical Center, Falls Church, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Perea","sequence":"additional","affiliation":[{"name":"Surgery, Division of Trauma and Acute Care Surgery, Lancaster General Health, Lancaster, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Huber","sequence":"additional","affiliation":[{"name":"Lancaster General Health, Lancaster, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malia","family":"Eischen","sequence":"additional","affiliation":[{"name":"Queen\u2019s Medical Center, Honolulu, Hawaii, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Akin","family":"Erol","sequence":"additional","affiliation":[{"name":"Queen\u2019s Medical Center, Honolulu, Hawaii, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7665-2775","authenticated-orcid":false,"given":"Michael Steven","family":"Farrell","sequence":"additional","affiliation":[{"name":"Surgery, University of California San Francisco, San Francisco, California, USA"},{"name":"Surgery, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Colom","sequence":"additional","affiliation":[{"name":"Lehigh Valley Health Network, Allentown, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Scott","sequence":"additional","affiliation":[{"name":"The University of Tennessee Medical Center, Knoxville, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4996-1502","authenticated-orcid":false,"given":"Brian","family":"Daley","sequence":"additional","affiliation":[{"name":"Surgical Critical Care, University of Tennessee Medical Center, Knoxville, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Bardes","sequence":"additional","affiliation":[{"name":"Trauma, Acute Care and Critical Care, West Virginia University Robert C Byrd Health Sciences Center, Morgantown, West Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Trauma, Acute Care Surgery and Critical Care, West Virginia University Health Sciences Center, Morgantown, West Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3378-9162","authenticated-orcid":false,"given":"Melissa","family":"Moncrief","sequence":"additional","affiliation":[{"name":"Trauma, Kettering Health Main Campus, Kettering, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"DeVoe","sequence":"additional","affiliation":[{"name":"Riverside Methodist Hospital, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6566-1833","authenticated-orcid":false,"given":"Ryan Peter","family":"Dumas","sequence":"additional","affiliation":[{"name":"UT Southwestern Medical, Dallas, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8178-5285","authenticated-orcid":false,"given":"Caitlin Anne","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"East Carolina University, Greenville, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Brigode","sequence":"additional","affiliation":[{"name":"Cook County Health, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D","family":"Berne","sequence":"additional","affiliation":[{"name":"Trauma Surgery, Broward Health Medical Center, Fort Lauderdale, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalier R","family":"Mederos","sequence":"additional","affiliation":[{"name":"Trauma Serevices, Broward Health, Fort Lauderdale, Florida, 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