{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T11:05:16Z","timestamp":1767092716301,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"25","license":[{"start":{"date-parts":[[2011,12,17]],"date-time":"2011-12-17T00:00:00Z","timestamp":1324080000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>\n                    Between November 5, 2007 and November 4, 2008, faecal samples from cattle and sheep submitted for diagnostic purposes to the Aberystwyth and Shrewsbury Veterinary Laboratories Agency (VLA) (now AHVLA) regional laboratories (covering North Wales and the West Midlands) were screened for the presence of\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    that produces CTX\u2010M extended\u2010spectrum \u03b2\u2010lactamase (ESBL) using the selective medium CHROMagar CTX. Samples from 113 farms were tested and eight ESBL\u2010positive farms identified. Of these, six farms were identified via submissions of cattle faeces and two from sheep. Gene sequencing revealed both group 1 and group 9 CTX\u2010M enzymes corresponding to CTX\u2010M\u201014, CTX\u2010M\u201014B (group 9) and CTX\u2010M\u201015\/28 (group 1). Analysis of these isolates by nanoarray revealed that some were carrying a range of virulence genes including\n                    <jats:italic>ireA<\/jats:italic>\n                    ,\n                    <jats:italic>iroN<\/jats:italic>\n                    and\n                    <jats:italic>prfB<\/jats:italic>\n                    , which have been associated with extraintestinal pathogenic\n                    <jats:italic>E coli<\/jats:italic>\n                    , and were multidrug resistant. Geographical analysis with choropleth maps suggested that these CTX\u2010M genes are relatively widespread in the North Wales and West Midlands study area. This work was carried out concurrently with the running of a VLA ESBL surveillance system, which has subsequently identified many more CTX\u2010M positive farms in the UK.\n                  <\/jats:p>","DOI":"10.1136\/vr.100037","type":"journal-article","created":{"date-parts":[[2011,10,21]],"date-time":"2011-10-21T21:51:40Z","timestamp":1319233900000},"page":"656-656","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Investigation of the presence of ESBL\u2010producing\n                    <i>Escherichia coli<\/i>\n                    in the North Wales and West Midlands areas of the UK in 2007 to 2008 using scanning surveillance"],"prefix":"10.1002","volume":"169","author":[{"given":"L. C.","family":"Snow","sequence":"first","affiliation":[{"name":"Animal Health Veterinary Laboratories Agency (AHVLA) \u2013 Centre for Epidemiology and Risk Analysis New Haw Addlestone Surrey KT15 3NB UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Wearing","sequence":"additional","affiliation":[{"name":"AHVLA \u2013 Department of Bacteriology Addlestone Surrey KT15 3NB UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Animal Health Veterinary Laboratories Agency (AHVLA) \u2013 Centre for Epidemiology and Risk Analysis New Haw Addlestone Surrey KT15 3NB UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Teale","sequence":"additional","affiliation":[{"name":"AHVLA \u2013 Shrewsbury Kendal Road, Harlescott Shrewsbury Shropshire SY1 4HD UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. G.","family":"Coldham","sequence":"additional","affiliation":[{"name":"AHVLA \u2013 Department of Bacteriology Addlestone Surrey KT15 3NB UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00419-07"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.11.017"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00354-08"},{"key":"e_1_2_6_5_1","unstructured":"Defra(2007)Extended\u2010Spectrum Beta\u2010Lactamases (ESBL) in Bacteria Associated with Animals \u2010 Defra Position.www.defra.gov.uk\/foodfarm\/farmanimal\/diseases\/atoz\/zoonoses\/esbl.htm. 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Accessed March 1 2011"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl483"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki239"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn485"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq396"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl559"},{"key":"e_1_2_6_14_1","first-page":"186","article-title":"Extended\u2010spectrum beta\u2010lactamase detected in E coli recovered from calves in Wales.","volume":"156","author":"Teale C. 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