{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:15:49Z","timestamp":1784780149257,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2012,6,16]],"date-time":"2012-06-16T00:00:00Z","timestamp":1339804800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>\n                    <jats:bold>Time\u2010domain heart rate variability (HRV) parameters and the correlation between echocardiography and Holter examinations in dogs with myxomatous mitral valve disease (MMVD) were determined. Holter examination was also performed at different time frames: an entire 24\u2010hour period, a four\u2010hour period during sleep, and a four\u2010hour period while awake. Ten healthy (control group) and 28\u00a0MMVD dogs, 15 with and 13 without heart failure, were evaluated. The SDANN (sd of the mean normal RR intervals for all five\u2010minute segments during 24\u2010hour Holter) and pNN<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>50<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:bold>(percentage of differences between adjacent normal RR intervals that are &gt;50\u00a0ms computed over 24\u2010hour Holter) variables were significantly lower in the dogs with MMVD heart failure. The differences in HRV between the groups were only detected during the 24\u2010hour evaluation period (P\u2009&lt;\u20090.05). There were high correlations (canonical analysis) between Holter and echocardiography examinations when considering pNN<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>50<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:bold>, SDANN, and LA\/AO (left atrial to aortic root ratio) (r\u2009=\u20090.92; P\u2009&lt;\u20090.05), indicating that both are important in evaluating MMVD dogs. SDANN and pNN<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>50<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:bold>are measures of parasympathetic control of the heart, and thus, it is possible to infer that the MMVD dogs exhibit parasympathetic withdrawal during the development of heart failure.<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1136\/vr.100202","type":"journal-article","created":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T23:17:35Z","timestamp":1338333455000},"page":"622-622","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Heart rate variability parameters of myxomatous mitral valve disease in dogs with and without heart failure obtained using 24\u2010hour Holter electrocardiography"],"prefix":"10.1002","volume":"170","author":[{"given":"M. S.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Departamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Escola de Veterin\u00e1ria Universidade Federal de Minas Gerais Belo Horizonte Minas Gerais Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A. L.","family":"Muzzi","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Veterin\u00e1ria Universidade Federal de Lavras Lavras Minas Gerais Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. B.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Exatas Universidade Federal de Lavras Lavras Minas Gerais Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. A. L.","family":"Muzzi","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Escola de Veterin\u00e1ria Universidade Federal de Minas Gerais Belo Horizonte Minas Gerais Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. F.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Escola de Veterin\u00e1ria Universidade Federal de Minas Gerais Belo Horizonte Minas Gerais Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Escola de Veterin\u00e1ria Universidade Federal de Minas Gerais Belo Horizonte Minas Gerais Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. F.","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Escola de Veterin\u00e1ria Universidade Federal de Minas Gerais Belo Horizonte Minas Gerais Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0392.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-011-9892-0"},{"key":"e_1_2_6_4_2","article-title":"The echocardiographic examination. In Manual of Veterinary Echocardiography","author":"Boon J. 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