{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T04:50:09Z","timestamp":1775451009076,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,5]],"date-time":"2013-01-05T00:00:00Z","timestamp":1357344000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>We describe a case of zinc toxicity in a 14\u2010month\u2010old, female, neutered, Cavalier King Charles spaniel with a 48\u2010hour history of haematochezia, icterus and collapse. Regenerative anaemia with a packed\u2010cell volume of 7 per cent was seen. Prior to referral, radiography had revealed a gastric, metallic foreign body which was removed at exploratory laparotomy. On presentation, the dog was comatose, hypothermic and bradycardic \u2013 resuscitation was performed successfully, but the dog then displayed marked abdominal pain. The dog died 12 hours after presentation. At postmortem examination, the animal showed severe icterus. Both kidneys were diffusely dark red; the pancreas was diffusely pale and nodular. Histopathological examination revealed evidence of intravascular haemolysis with blood vessel lumens containing haemoglobin. The renal tubules also contained large amounts of intraluminal haemoglobin with haemoglobin crystals scattered throughout the cortex and medulla. The pancreas exhibited multifocal coagulative necrosis, surrounded by a neutrophil\u2010dominated inflammatory infiltrate. Zinc levels were markedly increased above the normal reference range in both liver and kidney. This report describes the clinical and pathological findings of a case of acute zinc toxicity in a dog following ingestion of a metallic object which resulted in marked haemolytic anaemia and acute pancreatitis.<\/jats:p>","DOI":"10.1136\/vr.100376","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T20:55:57Z","timestamp":1353704157000},"page":"17-17","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Haemolytic anaemia and acute pancreatitis associated with zinc toxicosis in a dog"],"prefix":"10.1002","volume":"172","author":[{"given":"R.","family":"Blundell","sequence":"first","affiliation":[{"name":"Small Animal Teaching Hospital School of Veterinary Science University of Liverpool Chester High Road Neston CH64 7TE UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Adam","sequence":"additional","affiliation":[{"name":"Veterinary Pathology School of Veterinary Science University of Liverpool Chester High Road Neston CH64 7TE UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,5]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.d365"},{"key":"e_1_2_3_3_1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.tvjl.2006.08.015","article-title":"Heinz body haemolytic anaemia in a dog secondary to ingestion of a zinc toy: a case report","volume":"174","author":"Bexfield N.","year":"2007","journal-title":"Veterinary Jour\u2010nal"},{"key":"e_1_2_3_4_1","first-page":"676","article-title":"[Acute zinc poi\u2010soning in a dog]","volume":"129","author":"Borst G. 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