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In people, APP levels have been shown to correlate both with the extent of disease and also the prognosis in several forms of neoplasia, including prostate, oesophageal and colorectal cancer. As such, they can be used as prognostic and monitoring tools. To date, similar studies in veterinary patients have been limited, largely retrospective in nature and many are non\u2010specific for tumour type. The purpose of this study was to evaluate a panel of four APPs in dogs with naturally occurring mast cell tumours (MCTs) and sarcomas to identify in the first instance whether increased levels of individual APPs, or identifiable combinations of APPs, was linked with the presence of disease. In the patients with MCTs, C\u2010reactive protein (CRP) and \u03b1\u20101 acid glycoprotein levels increased, with a concurrent drop in serum amyloid A levels. In the sarcoma patients, CRP, \u03b1\u20101 acid glycoprotein and haptoglobin were increased. These findings suggest that specific solid tumour types in dogs may be associated with specific changes in APP profiles.<\/jats:p>","DOI":"10.1136\/vr.100401","type":"journal-article","created":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T20:49:50Z","timestamp":1338583790000},"page":"648-648","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Acute phase protein levels in dogs with mast cell tumours and sarcomas"],"prefix":"10.1002","volume":"170","author":[{"given":"D.","family":"Chase","sequence":"first","affiliation":[{"name":"Pride Veterinary Centre Riverside Road Derby Derbyshire DE24 8HX UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"McLauchlan","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Garscube Estate, 464 Bearsden Road Glasgow G61 1QH UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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