{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:35:52Z","timestamp":1778279752532,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,8,4]],"date-time":"2012-08-04T00:00:00Z","timestamp":1344038400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>\n                    A prospective, randomised, blinded controlled study was performed to determine the anaesthetic and cardiorespiratory effects of a constant\u2010rate infusion (CRI) of alfaxalone in 12 sheep anaesthetised with desflurane, and undergoing experimental orthopaedic surgery. Sheep were sedated with dexmedetomidine (4 \u03bcg\/kg, intravenously) and butorphanol (0.3\u00a0mg\/kg, intravenously). Anaesthesia was induced with alfaxalone (1\u00a0mg\/kg\/minute to effect, intravenously) and maintained with desflurane in oxygen and alfaxalone 0.07\u00a0mg\/kg\/minute or saline for 150\u00a0minutes (range 150\u2013166\u00a0minutes). The anaesthetic induction dose of alfaxalone, the desflurane expiratory fraction required for anaesthetic maintenance, cardiorespiratory measurements and blood\u2010gases were recorded at predetermined intervals. Quality of sedation, anaesthetic induction and recovery were assessed. The alfaxalone induction dose was 1.7\u00a0mg\/kg (1.2 to 2.6\u00a0mg\/kg). The desflurane expiratory fraction was lower (22 per cent) in sheep receiving alfaxalone CRI (P\u2009=\u20090). Also, heart rate (P\u2009=\u20090), cardiac index (P\u2009=\u20090.002), stroke index (P\u2009=\u20090) and contractility (P\u2009=\u20090) were higher, and systemic vascular resistance (P\u2009=\u20090.002) was lower. Although respiratory rate tended to be higher with alfaxalone, there was no difference in PCO\n                    <jats:sub>2<\/jats:sub>\n                    between the groups. Recovery times were significantly longer in sheep given alfaxalone (25.4\u00a0v 9.5\u00a0minutes) but recovery quality was similar. Alfaxalone reduced requirements of desflurane and maintained similar cardiorespiratory function, but recovery time was more prolonged.\n                  <\/jats:p>","DOI":"10.1136\/vr.100487","type":"journal-article","created":{"date-parts":[[2012,7,12]],"date-time":"2012-07-12T00:13:45Z","timestamp":1342052025000},"page":"125-125","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Anaesthetic and cardiorespiratory effects of a constant\u2010rate infusion of alfaxalone in desflurane\u2010anaesthetised sheep"],"prefix":"10.1002","volume":"171","author":[{"given":"M.","family":"del Mar Granados","sequence":"first","affiliation":[{"name":"Department of Animal Medicine and Surgery, Anaesthesia Unit Veterinary Faculty University of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Manuel","family":"Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, Anaesthesia Unit Veterinary Faculty University of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fern\u00e1ndez\u2010Sarmiento","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, Anaesthesia Unit Veterinary Faculty University of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. Javier","family":"Funes","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, Anaesthesia Unit Veterinary Faculty University of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Morgaz","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, Anaesthesia Unit Veterinary Faculty University of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Navarrete","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, Anaesthesia Unit Veterinary Faculty University of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ma Carrillo","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery Veterinary Faculty CEU\u2010Cardenal Herrera University Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rubio","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery Veterinary Faculty CEU\u2010Cardenal Herrera University Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Mu\u00f1oz\u2010Rasc\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, Anaesthesia Unit Veterinary Faculty University of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. A.","family":"G\u00f3mez de Segura","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery Veterinary Faculty Complutense University of Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"G\u00f3mez\u2010Villamandos","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, Anaesthesia Unit Veterinary Faculty University of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.69.11.1391"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2011.03.017"},{"key":"e_1_2_6_4_2","first-page":"1","article-title":"Evaluation of transpulmonary thermodilution as a method to measure cardiac output in anaesthetized cats","volume":"73","author":"Beaulieu K. 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