{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:00:54Z","timestamp":1788184854515,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2013,5,18]],"date-time":"2013-05-18T00:00:00Z","timestamp":1368835200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>\n                    Postnatal mixed respiratory\u2010metabolic acidosis is common in calves, and depending on its severity can impair vitality or even cause death. Carbon dioxide accounts for the respiratory component and L\u2010lactate for the metabolic component of the mixed acidosis, but it remains unclear which component determines the severity and duration of the acidosis. In a first attempt to clarify, this was investigated retrospectively in 31\u00a0calves during the first two hours of life, and in 13\u00a0calves during the first three days of life. Venous blood was collected for blood gas analysis and measurement of acid\u2010base variables and L\u2010lactate concentration. pH Was more strongly correlated with L\u2010lactate concentration (r\n                    <jats:sup>2<\/jats:sup>\n                    =0.808) than with partial pressure of CO\n                    <jats:sub>2<\/jats:sub>\n                    (pCO\n                    <jats:sub>2<\/jats:sub>\n                    , r\n                    <jats:sup>2<\/jats:sup>\n                    =0.418). Duration of parturition had a distinct effect on pH and L\u2010lactate concentration but not on pCO\n                    <jats:sub>2<\/jats:sub>\n                    ; calves born within six hours of rupture of the allantoic sac had a higher pH and lower L\u2010lactate concentration than calves born after a longer duration of parturition (both P&lt;0.01). Normalisation of pCO\n                    <jats:sub>2<\/jats:sub>\n                    took four hours and normalisation of L\u2010lactate took 48 hours. It was concluded that L\u2010lactate is a more important factor in the pathogenesis of acidosis than pCO\n                    <jats:sub>2<\/jats:sub>\n                    , and that the duration of metabolic acidosis exceeds that of respiratory acidosis in perinatal asphyxia of calves.\n                  <\/jats:p>","DOI":"10.1136\/vr.101192","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T23:25:34Z","timestamp":1363217134000},"page":"528-528","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["The effect of lactic acidosis on the generation and compensation of mixed respiratory\u2010metabolic acidosis in neonatal calves"],"prefix":"10.1002","volume":"172","author":[{"given":"U.","family":"Bleul","sequence":"first","affiliation":[{"name":"First Clinic for Reproductive Medicine Department of Food Animals Vetsuisse\u2010Faculty Clinic of Reproductive Medicine University of Zurich Winterthurerstr.260, CH 8057 Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"G\u00f6tz","sequence":"additional","affiliation":[{"name":"First Clinic for Reproductive Medicine Department of Food Animals Vetsuisse\u2010Faculty Clinic of Reproductive Medicine University of Zurich Winterthurerstr.260, CH 8057 Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00063.2007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc1518"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2010.07.022"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.161.20.688"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.8.850"},{"key":"e_1_2_7_7_1","unstructured":"BornE.(1981)Untersuchungen \u00fcber den Einfluss der Schnittentbindung auf die Vitalit\u00e4t neugeborener K\u00e4lber. 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M.","year":"2000"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.41.219.472"},{"key":"e_1_2_7_21_1","first-page":"95","article-title":"Untersuchungen \u00fcber die Blutgase, den S\u00e4ure\u2010Basen\u2010Haushalt, Elektrolytgehalt, einige Enzyme und Inhaltsstoffe im Blut neugeborener K\u00e4lber","volume":"86","author":"Schlerka G.","year":"1979","journal-title":"Deutsche Tier\u00e4rztliche Wochenschrift"},{"key":"e_1_2_7_22_1","volume-title":"Aspects of Obstetrical Perinatology in Cattle","author":"Schuijt G.","year":"1992"},{"key":"e_1_2_7_23_1","unstructured":"SorgeU.(2005)Untersuchungen zum Einfluss einer variierten Vorbereitungsdauer auf das Auftreten von Schwergeburten und der perinatalen Mortalit\u00e4t bei K\u00e4lbern primiparer Rinder. 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