{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:42:02Z","timestamp":1761648122950,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,25]],"date-time":"2014-01-25T00:00:00Z","timestamp":1390608000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>\n                    Ten New Zealand White rabbits were used in a crossover experimental study: 200 \u00b5g\/kg medetomidine and 1 (M1) or 2\u00a0mg\/kg (M2) morphine were administered intramuscularly. After preoxygenation, anaesthesia was induced with alfaxalone at 10\u00a0mg\/kg intravenously. The trachea was intubated and 60 per cent oxygen provided. Heart and respiratory rates (HR and RR), direct arterial pressures (APs), arterial pH (pHa), PaO\n                    <jats:sub>2<\/jats:sub>\n                    , PaCO\n                    <jats:sub>2<\/jats:sub>\n                    and SaO\n                    <jats:sub>2<\/jats:sub>\n                    were taken at baseline, after premedication and every 10\u00a0minutes during the 90\u00a0minutes following induction. The times to return the ear pinch, toe pinch and righting reflexes were recorded. Data were analysed using a two\u2010way analysis of variance and a paired samples t test. Compared to baseline values, HR, RR, APs, PaO\n                    <jats:sub>2<\/jats:sub>\n                    and SaO\n                    <jats:sub>2<\/jats:sub>\n                    decreased significantly after premedication in both groups. Postinduction apnoea of 20\u00b110 with M1 and 27\u00b118\u00a0minutes with M2 was experienced following alfaxalone administration, intermitent positive pressure ventilation was applied until spontaneous breathing efforts appeared. Cardiovascular variables, RR and pHa remained below, and PaCO\n                    <jats:sub>2<\/jats:sub>\n                    over baseline values during the anaesthetic period. No significant differences were observed in the recovery times. Morphine at 1 or 2\u00a0mg\/kg combined with medetomidine and alfaxalone in rabbits produced a suitable level of anaesthesia, although profound cardiorespiratory depression was found.\n                  <\/jats:p>","DOI":"10.1136\/vr.101293","type":"journal-article","created":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T21:05:07Z","timestamp":1389301507000},"page":"95-95","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Cardiorespiratory, anaesthetic and recovery effects of morphine combined with medetomidine and alfaxalone in rabbits"],"prefix":"10.1002","volume":"174","author":[{"given":"R.","family":"Navarrete\u2010Calvo","sequence":"first","affiliation":[{"name":"Department of Animal Medicine and Surgery Scholl of Veterinary Medicine University of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"G\u00f3mez\u2010Villamandos","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery Scholl of Veterinary Medicine University of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Morgaz","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery Scholl of Veterinary Medicine University of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Manuel Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery Scholl of Veterinary Medicine University of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fern\u00e1ndez\u2010Sarmiento","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery Scholl of Veterinary Medicine University of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Mu\u00f1oz\u2010Rasc\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery Scholl of Veterinary Medicine University of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"L\u00f3pez Villalba","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery Scholl of Veterinary Medicine University of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Del Mar Granados","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery Scholl of Veterinary Medicine University of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-469235-0.50020-8"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","DOI":"10.1097\/00000542-198909001-00543","article-title":"Dexmedetomidine: hemodynamic changes in autonomically denervated dogs","volume":"71","author":"Flacke J. 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