{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:34:12Z","timestamp":1767897252748,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,13]],"date-time":"2013-07-13T00:00:00Z","timestamp":1373673600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>Nineteen dogs with vesico\u2010urethral reflex dyssynergia (VURD) were treated with prazosin or terazosin 0.5\u00a0mg\/kg twice daily to compare efficacy and side effects. Dogs were referred because of signs of (partial) urethral obstruction. Physical examination, abdominal ultrasonography, urinalysis and a radiographic contrast study of bladder and urethra (urethrocystography) were routinely performed. If no mechanical causes of obstruction or disease of the distal urinary tract were observed, the diagnosis VURD was presumed and the dogs were included in our study. Follow\u2010up information was obtained from owners or referring veterinarians. Significantly more side effects were seen in the dogs treated with terazosin (n=14; 93 per cent) compared with the dogs treated with prazosin (n=5; 20 per cent; P=0.002). Effects of the treatment were comparable between prazosin and terazosin. Labradors and dogs that were castrated surgically had a significant better survival (P&lt;0.01) compared with other breeds and animals that were castrated chemically. There was a moderate to good effect in 60 per cent of the dogs treated with prazosin, and in 64 per cent of the dogs treated with terazosin.<\/jats:p>","DOI":"10.1136\/vr.101326","type":"journal-article","created":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T20:36:42Z","timestamp":1371674202000},"page":"41-41","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of terazosin and prazosin for treatment of vesico\u2010urethral reflex dyssynergia in dogs"],"prefix":"10.1002","volume":"173","author":[{"given":"A. N.","family":"Haagsman","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine Utrecht University Yalelaan 108 Utrecht Utrecht 3584 CM The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kummeling","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Utrecht University Yalelaan 108 Utrecht Utrecht 3584 CM The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"Moes","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Utrecht University Yalelaan 108 Utrecht Utrecht 3584 CM The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Mesu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacy Faculty of Veterinary Medicine Utrecht University Yalelaan 108 Utrecht Utrecht 3584 CM The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kirpensteijn","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Utrecht University Yalelaan 108 Utrecht Utrecht 3584 CM The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01302-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.230.8.1184"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1993.tb16298.x"},{"issue":"4","key":"e_1_2_6_5_1","first-page":"S22","article-title":"A Comparison of varying \u03b1\u2010blockers and other pharmacotherapy options for lower urinary tract symptoms","volume":"7","author":"Chapple R.","year":"2005","journal-title":"Reviews in Urology"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.02.037"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1998.tb03648.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acuroe.2010.12.002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctsap.2004.12.009"},{"key":"e_1_2_6_10_1","first-page":"955","article-title":"Urination function reconstruction of atonic bladder with Finetech\u2010Brindley sacral anterior root stimulator: a preliminary study in a canine model","volume":"5","author":"Gui\u2010Bin Z.","year":"2010","journal-title":"Scientific Research and Essays"},{"key":"e_1_2_6_11_1","first-page":"121","volume":"12","author":"Holt P.","year":"1990","journal-title":"Companion Animal Practice: Dysuria in the dog Part 1: Management of the dysuric animal. In Practice"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2000.tb01498.x"},{"key":"e_1_2_6_13_1","first-page":"181","article-title":"Alpha blockers for the treatment of benign prostatic hyperplasia","volume":"9","author":"Lepor H.","year":"2007","journal-title":"Review in Urology"},{"key":"e_1_2_6_14_1","first-page":"695","volume-title":"Small Animal Internal Medicine","author":"Nelson R. W.","year":"2009"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2009.08.002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00599-4"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2042.2000.00175.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0022-3565(24)36869-7","article-title":"Relationships between pharmacokinetics and blockade of agonist\u2010induced prostatic intraurethral pressure and mean arterial pressure in the conscious dog after single and repeated daily oral administration of terazosin","volume":"282","author":"Witte D. G.","year":"1997","journal-title":"Journal of Phramacology and Experimental Therapeutics"},{"issue":"8","key":"e_1_2_6_19_1","first-page":"S142","article-title":"Botulinum toxin in neuro\u2010urological disorders","volume":"19","author":"Wolfgang H. J.","year":"2004","journal-title":"Movement Disorders"}],"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1136%2Fvr.101326","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/vr.101326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:39:29Z","timestamp":1761647969000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1136\/vr.101326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1136\/vr.101326"],"URL":"https:\/\/doi.org\/10.1136\/vr.101326","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7]]}}}