{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:26:00Z","timestamp":1778675160980,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,8,31]],"date-time":"2013-08-31T00:00:00Z","timestamp":1377907200000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>\n                    Drunken lamb syndrome (DLS) has recently been described as lamb D\u2010lactic acidosis syndrome (LDLAS). In 2012, 18 lambs aged between 7\u00a0days and 28\u00a0days with LDLAS were identified. Biochemically, each lamb had a metabolic acidosis characterised by D\u2010lactic acidosis and exhibited clinical signs including: not hyperthermic, no evidence of dehydration, demonstrating an ataxic gait tending to recumbency (DLS) and possibly somnolence. These lambs received 50\u00a0mmol of sodium bicarbonate as an 8.4 per cent solution given orally, together with parenteral long\u2010acting amoxicillin. All 18 cases made a full clinical recovery. This study demonstrates a novel effective treatment for a disease that is usually fatal, and also demonstrates a strong correlation between venous plasma bicarbonate concentrations and venous plasma D\u2010lactate concentrations (R\n                    <jats:sup>2<\/jats:sup>\n                    =0.49).\n                  <\/jats:p>","DOI":"10.1136\/vr.101536","type":"journal-article","created":{"date-parts":[[2013,6,29]],"date-time":"2013-06-29T00:18:54Z","timestamp":1372465134000},"page":"193-193","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Successful correction of D\u2010lactic acid neurotoxicity (drunken lamb syndrome) by bolus administration of oral sodium bicarbonate"],"prefix":"10.1002","volume":"173","author":[{"given":"J. W.","family":"Angell","sequence":"first","affiliation":[{"name":"Wern Veterinary Surgeons Greenfield Road Ruthin LL15 2PQ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. L.","family":"Jones","sequence":"additional","affiliation":[{"name":"Wern Veterinary Surgeons Greenfield Road Ruthin LL15 2PQ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Voigt","sequence":"additional","affiliation":[{"name":"Clinic for Ruminants LMU MUnich Sonnenstra\u00dfe 16 85764 Oberschlei\u00dfheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. H.","family":"Grove\u2010White","sequence":"additional","affiliation":[{"name":"Department of Animal Health and Welfare University of Liverpool Leahurst Campus, Chester High Road Neston CH64 7TE UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.101063"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb01819.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2004.tb02615.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.133.20.499"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.144.23.639"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.2460\/javma.1985.187.04.392","article-title":"Evaluation of sodium bicarbonate, sodium L\u2010lactate and sodium acetate for the treatment of acidosis in diarrheic calves","volume":"187","author":"Kasari T. R.","year":"1985","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.08.028"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.164.6.174"},{"key":"e_1_2_9_10_1","first-page":"794","volume-title":"Maxwell and Kleeman's Clinical Disorders of Fluid and Electrolyte Metabolism","author":"Narins R. G.","year":"1994"},{"key":"e_1_2_9_11_1","unstructured":"R\u2010Biopharm. (2013)Enzymatic Analysis D\u2010Lactic acid\/L\u2010Lactic acid. UV\u2010method for the determination of D\u2010 and L\u2010lactic acid in foodstuffs and other materials: datasheet. Darmstadt Germany"},{"key":"e_1_2_9_12_1","unstructured":"RadostitsO. M. GayC. C. BloodD. C. HinchcliffK. W. (2000)Veterinary Medicine. 9th edn. 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