{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T19:34:35Z","timestamp":1769456075007,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,3,8]],"date-time":"2014-03-08T00:00:00Z","timestamp":1394236800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>Sterile haemorrhagic cystitis (SHC) is a possible side effect of cyclophosphamide which can severely impact quality of life. Mesna and diuresis are effective in human medicine to prevent SHC. The aim of the present study was to compare the efficacy of mesna versus diuresis with furosemide in preventing SHC in dogs treated with cyclophosphamide within a multidrug chemotherapy induction protocol for malignant lymphoma. Medical records of dogs treated at the Clinic of Small Animal Medicine, Munich, between 1997 and 2009 were analysed retrospectively. Of the 131 dogs included, 33 received no prophylaxis (group 1), 43 received mesna (group 2), and 55 received furosemide (group 3). Age, gender, breed, bodyweight, body surface area, dose and application method of cyclophosphamide, and the method of SHC prophylaxis were compared between dogs with and without SHC. Six dogs (4.6 per cent) developed SHC. The incidence of SHC in groups 1, 2 and 3 was 4\/33 (12.1 per cent), 1\/43 (2.3 per cent), and 1\/55 (1.8 per cent), respectively. Dogs receiving either mesna or furosemide were significantly less likely to develop SHC (P=0.03). Otherwise no significant differences were found. In conclusion, this study demonstrates the efficacy and the medical indication of mesna and furosemide for prevention of cyclophosphamide\u2010induced SHC.<\/jats:p>","DOI":"10.1136\/vr.101574","type":"journal-article","created":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T20:14:45Z","timestamp":1390594485000},"page":"250-250","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Mesna and furosemide for prevention of cyclophosphamide\u2010induced sterile haemorrhagic cystitis in dogs \u2013 a retrospective study"],"prefix":"10.1002","volume":"174","author":[{"given":"S.","family":"Laberke","sequence":"first","affiliation":[{"name":"Clinic of Small Animal Medicine Ludwig Maximilian University Munich Veterin\u00e4rstr. 13 80539 Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Zenker","sequence":"additional","affiliation":[{"name":"University of California, Davis School of Veterinary Medicine Department of Radiation Oncology 1 Shields Avenue Davis CA 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hirschberger","sequence":"additional","affiliation":[{"name":"Clinic of Small Animal Medicine Ludwig Maximilian University Munich Veterin\u00e4rstr. 13 80539 Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000012062"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-36-5-395"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00410691"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(82)90143-2"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.2.194"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.222.1388"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2000.tb02224.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(79)90222-3"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2460\/javma.1977.171.03.259","article-title":"Cyclophosphamide\u2010induced cystitis in the dog and cat","volume":"71","author":"Crow S. E.","year":"1977","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(82)90633-1"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0179.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb02868.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01612769"},{"key":"e_1_2_5_15_1","doi-asserted-by":"crossref","unstructured":"GaetaR. BrownD. CohenR. SorenmoK.(2012)Risk factors for development of sterile haemorrhagic cystitis in canine lymphoma patients receiving oral cyclophosphamide: a case\u2010control study.Veterinary and Comparative Oncologyhttps:\/\/doi.org\/10.1111\/vco.12009","DOI":"10.1111\/vco.12009"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2002.tb02411.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1200\/JCO.1998.16.2.616","article-title":"Pharmacokinetics of an intravenous\u2010oral versus intravenous\u2010mesna regimen in lung cancer patients receiving ifosfamide","volume":"16","author":"Goren M. P.","year":"1998","journal-title":"Journal of Clinical Oncology"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002800050673"},{"key":"e_1_2_5_19_1","first-page":"164","article-title":"Nebenwirkungen der Chemotherapie beim Hund. Mehrkomponenten\u2010Chemotherapie des kaninen malignen Lymphoms","volume":"28","author":"Hirschberger J.","year":"2000","journal-title":"Tier\u00e4rztliche Praxis"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb01959.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1984.252"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1987.tb03092.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/pbc.20617","article-title":"Adverse hypersensitivity reactions to mesna as adjunctive therapy for cyclophosphamide","volume":"49","author":"Khaw S. L.","year":"2005","journal-title":"Pediatric Blood & Cancer"},{"key":"e_1_2_5_24_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2460\/javma.1988.193.02.233","article-title":"Treatment of cyclophosphamide\u2010induced hemorrhagic cystitis in five dogs","volume":"193","author":"Laing E. J.","year":"1988","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365590701570953"},{"key":"e_1_2_5_26_1","first-page":"5829","article-title":"Crossover randomized comparison of intravenous versus intravenous\/oral mesna in soft tissue sarcoma treated with high\u2010dose ifosfamide","volume":"9","author":"Mace J. R.","year":"2003","journal-title":"Clinical Cancer Research"},{"key":"e_1_2_5_27_1","first-page":"240","article-title":"Hemorrhagic cystitis in a dog","volume":"37","author":"Marin M. P.","year":"1996","journal-title":"The Canadian Veterinary Journal"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2001.tb02328.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2003.00027.x"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1997.tb00476.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.2460\/javma.1992.201.10.1572","article-title":"Acute sterile hemorrhagic cystitis after a single intravenous administration of cyclophosphamide in three dogs","volume":"201","author":"Peterson J. L.","year":"1992","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2000.tb01166.x"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.67.3.510"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.11.2016"},{"key":"e_1_2_5_35_1","first-page":"52","article-title":"Evaluation of an actinomycin\u2010D\u2010containing combination chemotherapy protocol with extended maintenance therapy for canine lymphoma","volume":"47","author":"Siedlecki C. T.","year":"2006","journal-title":"The Canadian Veterinary Journal"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.232.6.879"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb01810.x"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880201)61:3<451::AID-CNCR2820610308>3.0.CO;2-G"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2004.0053b.x"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1998.tb02151.x"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.c5081"}],"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1136%2Fvr.101574","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/vr.101574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T12:13:43Z","timestamp":1761653623000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1136\/vr.101574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1136\/vr.101574"],"URL":"https:\/\/doi.org\/10.1136\/vr.101574","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}