{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:37:12Z","timestamp":1790689032919,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2013,11,2]],"date-time":"2013-11-02T00:00:00Z","timestamp":1383350400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>Antihistaminic drugs are commonly used as symptomatic therapy of atopic dermatitis in dogs. Unfortunately, their clinical benefit is largely unsubstantiated. In a double\u2010blinded, placebo\u2010controlled, cross\u2010over trial, the influence of dimetinden and of a combination of chlorpheniramine and hydroxyzine on pruritus and lesions was evaluated in 19 dogs. They were treated with either product or a placebo orally for 14\u00a0days, each time followed by a 14\u2010day washout period. Before and after each period, the dogs were examined and the Canine Atopic Dermatitis Extent and Severity Index (CADESI) determined by a clinician, and the pruritus and general condition by the owner. Dimetinden improved the pruritus significantly (P=0.014) but not the CADESI (P=0.087), the combination of hydroxyzine and chlorpheniramine improved the CADESI (P=0.049) and pruritus (P=0.05) significantly. Ten of 17 dogs improved by more than 25 per cent in pruritus with the combination of hydroxyzine and chlorpheniramine, 12 of 18 with dimetindenmaleate and only 2 of 19 with placebo. Antihistamines can help to reduce pruritus in atopic dogs, but in most cases, the improvement is limited and additional treatment may be needed.<\/jats:p>","DOI":"10.1136\/vr.101907","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T11:26:38Z","timestamp":1381490798000},"page":"423-423","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy of dimetinden and hydroxyzine\/chlorpheniramine in atopic dogs: a randomised, controlled, double\u2010blinded trial"],"prefix":"10.1002","volume":"173","author":[{"given":"M.","family":"Eichenseer","sequence":"first","affiliation":[{"name":"Clinic of Small Animal Medicine Centre for Clinical Veterinary Medicine Ludwig Maximilian University Munich Munich 80539 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Clinic of Small Animal Medicine Centre for Clinical Veterinary Medicine Ludwig Maximilian University Munich Munich 80539 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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