{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:12:26Z","timestamp":1788599546835,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,3,22]],"date-time":"2014-03-22T00:00:00Z","timestamp":1395446400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>\n                    The efficacy of an\n                    <jats:italic>Actinobacillus pleuropneumoniae<\/jats:italic>\n                    subunit vaccine based on ApxIA, ApxIIA, ApxIIIA and OMP\u20102 (Porcilis App, MSD) was investigated in two farrow\u2010to\u2010finish pig herds (A and B) affected by chronic pleurisy. In total, 1161 pigs were included. At three weeks of age, the pigs were randomly allocated to non\u2010vaccinated control (NV; n=580) and vaccinated (V; n=581) groups. At 6 and 10 weeks of age, pigs were injected with Porcilis\u2010APP (V group) or adjuvant (NV group). At slaughter (26 weeks), pleurisy and pneumonia lesions were assessed. All pigs were weighed individually at 6 and 26 weeks of age, and average daily weight gain (ADG; g\/pig\/day) was calculated. Mortality and days of additional treatment (DAT) were registered during the whole experiment. Data were analysed using binary logistic regression or analysis of variance for proportions or continuous variables, respectively. The prevalence of pleurisy and pneumonia was (NV\u2010A=19.3, V\u2010A=7.9, (P=0.000); NV\u2010B=17.9, V\u2010B=0.7, (P=0.000)) and (NV\u2010A=42.4, V\u2010A=21.2, (P=0.000); NV\u2010B=46.7, V\u2010B=19.0, (P=0.000)), respectively. The ADG was NV\u2010A=632\u00b1157, V\u2010A=647\u00b191, (P=0.162); NV\u2010B=660\u00b1115, V\u2010B=670\u00b182, (P=0.232). The mortality during the experiment was NV\u2010A=5.7, V\u2010A=1.8, (P=0.015); NV\u2010B=2.3, V\u2010B=1.0, (P=0.170) per cent. The DAT was: NV\u2010A=15.04\u00b11.41, V\u2010A=14.95\u00b10.67, (P=0.010); NV\u2010B=21.68\u00b12.43, V\u2010B=16.99\u00b10.62, (P=0.000). The present study showed a significant reduction of the prevalence of pleurisy and pneumonia, and antimicrobial use in V pigs from both herds, and in mortality in V pigs from one herd.\n                  <\/jats:p>","DOI":"10.1136\/vr.101961","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T21:04:53Z","timestamp":1392843893000},"page":"302-302","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Efficacy of vaccination against\n                    <i>Actinobacillus pleuropneumoniae<\/i>\n                    in two Belgian farrow\u2010to\u2010finish pig herds with a history of chronic pleurisy"],"prefix":"10.1002","volume":"174","author":[{"given":"R.","family":"Del Pozo Sacrist\u00e1n","sequence":"first","affiliation":[{"name":"Unit Porcine Health Management, Department of Reproduction Obstetrics and Herd Health Faculty of Veterinary Medicine Ghent University Salisburylaan 133 Merelbeke 9820 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Michiels","sequence":"additional","affiliation":[{"name":"Unit Porcine Health Management, Department of Reproduction Obstetrics and Herd Health Faculty of Veterinary Medicine Ghent University Salisburylaan 133 Merelbeke 9820 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Martens","sequence":"additional","affiliation":[{"name":"Intervet International MSD Animal Health Wim de K\u00f6rverstraat 35 Boxmeer 5831 The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Haesebrouck","sequence":"additional","affiliation":[{"name":"Department of Pathology Bacteriology and Avian Diseases Faculty of Veterinary Medicine Ghent University Salisburylaan 133 Merelbeke 9820 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Maes","sequence":"additional","affiliation":[{"name":"Unit Porcine Health Management, Department of Reproduction Obstetrics and Herd Health Faculty of Veterinary Medicine Ghent University Salisburylaan 133 Merelbeke 9820 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.32.11.2749-2754.1994"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1051\/vetres\/2010037"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(01)00518-1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1998.9694841"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2004.01.004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1466252300000074"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2011.11.002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.12.001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.2460\/javma.1994.204.09.1334","article-title":"Porcine pleuropneumonia","volume":"204","author":"Fenwick B.","year":"1994","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2009.03.029"},{"key":"e_1_2_6_12_1","first-page":"653","volume-title":"Diseases of Swine","author":"Gottschalk M.","year":"2012"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.17221\/5826-VETMED","article-title":"Porcine pleuropneumonia: the first evaluation of field efficacy of a subunit vaccine in Croatia","volume":"47","author":"Habrun B.","year":"2002","journal-title":"Veterinary Medicine \u2013 Czech"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(97)00162-4"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2004.03.002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.54846\/jshap\/533","article-title":"Efficacy of a subunit vaccine against Actinobacillus pleuropneumoniae in an endemically infected swine herd","volume":"16","author":"Jirawattanapong P.","year":"2008","journal-title":"Journal of Swine Health Production"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2001133"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2011.11.009"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2009.12.027"},{"key":"e_1_2_6_20_1","first-page":"381","article-title":"Comparison of methods for assessing the prevalence and extent of pneumonia in market weight swine","volume":"26","author":"Morrison R. 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