{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:40:29Z","timestamp":1778589629287,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,2,21]],"date-time":"2015-02-21T00:00:00Z","timestamp":1424476800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>\n                    There is limited, useful, scientific information on detomidine in donkeys. This study compared the effects of intravenous saline, detomidine (10, 13.5, 17 and 20 \u03bcg\/kg) and acepromazine (50 \u03bcg\/kg) in donkeys by computing areas under the curve for 0\u201330, 30\u201360 and 60\u2013120\u00a0minutes (AUC\n                    <jats:sub>0\u201330<\/jats:sub>\n                    , AUC\n                    <jats:sub>30\u201360<\/jats:sub>\n                    and AUC\n                    <jats:sub>60\u2013120<\/jats:sub>\n                    ) for sedation scores, head heights and mechanical nociceptive thresholds (MNTs). For sedation scores, all detomidine treatments, except 10 \u03bcg\/kg, increased AUC\n                    <jats:sub>0\u201330<\/jats:sub>\n                    values compared with saline, and AUC\n                    <jats:sub>0\u201330<\/jats:sub>\n                    values were larger for 17 \u03bcg\/kg detomidine than for acepromazine. All head height AUC values were lower for detomidine than for saline (except AUC\n                    <jats:sub>60\u2013120<\/jats:sub>\n                    for 10 \u03bcg\/kg detomidine) and acepromazine (except AUC\n                    <jats:sub>0\u201330<\/jats:sub>\n                    for 10 and 20 \u03bcg\/kg detomidine, and AUC\n                    <jats:sub>60\u2013120<\/jats:sub>\n                    for 10 \u03bcg\/kg detomidine). For MNTs, all detomidine treatments increased AUC\n                    <jats:sub>0\u201330<\/jats:sub>\n                    and AUC\n                    <jats:sub>30\u201360<\/jats:sub>\n                    values compared with saline and acepromazine; AUC\n                    <jats:sub>30\u201360<\/jats:sub>\n                    values were smaller for 10 \u03bcg\/kg than for 17 and 20 \u03bcg\/kg detomidine. MNT AUC\n                    <jats:sub>60\u2013120<\/jats:sub>\n                    values were larger for 20 \u03bcg\/kg detomidine than for saline, 10 \u03bcg\/kg detomidine and acepromazine. Detomidine induced sedation and antinociception, but only antinociception was dosage dependent. Selection of detomidine dosage for donkeys may depend on the required duration of sedation and\/or degree of analgesia.\n                  <\/jats:p>","DOI":"10.1136\/vr.102569","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T10:54:25Z","timestamp":1417172065000},"page":"202-202","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Sedation and mechanical antinociception after intravenous administration of detomidine in donkeys: a dosage\u2013effect study"],"prefix":"10.1002","volume":"176","author":[{"given":"Ignacio","family":"Lizarraga","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Ross University School of Veterinary Medicine PO Box 334 Basseterre Saint Kitts and Nevis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Castillo\u2010Alcala","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Ross University School of Veterinary Medicine PO Box 334 Basseterre Saint Kitts and Nevis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelley M.","family":"Varner","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Ross University School of Veterinary Medicine PO Box 334 Basseterre Saint Kitts and Nevis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren S.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Ross University School of Veterinary Medicine PO Box 334 Basseterre Saint Kitts and Nevis"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,21]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"234","volume-title":"Manual of Equine Anesthesia and Analgesia","author":"ANONYMOUS","year":"2006"},{"key":"e_1_2_6_3_1","unstructured":"CHAMBERS J. 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