{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T19:33:35Z","timestamp":1769369615664,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,17]],"date-time":"2015-01-17T00:00:00Z","timestamp":1421452800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>\n                    The purpose of this randomised trial was to compare the effects of alfaxalone and propofol on tear production (STT\u20101), intraocular pressure (IOP) and globe position (GP) in healthy dogs. Fourteen Beagles were randomly divided into two groups; dogs in one group received alfaxalone (3\u00a0mg\/kg) (n=7) and dogs in the other group received propofol (6\u00a0mg\/kg) (n=7), both administered intravenously. IOP and GP were evaluated at basal time (T\n                    <jats:sub>b<\/jats:sub>\n                    ) and T\n                    <jats:sub>2,5,10,15,20,25&amp;30<\/jats:sub>\n                    (minutes after complete drug administration). STT\u20101 was evaluated at T\n                    <jats:sub>b<\/jats:sub>\n                    and T\n                    <jats:sub>10,20&amp;30<\/jats:sub>\n                    . STT\u20101 and IOP results were analysed using analysis of variance and GP was analysed using the likelihood ratio \u03c7\n                    <jats:sup>2<\/jats:sup>\n                    test. Dogs in the alfaxalone group showed a significant reduction in STT\u20101 at T\n                    <jats:sub>10&amp;20<\/jats:sub>\n                    (P&lt;0.05), while the propofol group did not show statistically significant differences in this parameter over time. Both anaesthetic drugs produced a transient elevation of IOP at T\n                    <jats:sub>2<\/jats:sub>\n                    (P&gt;0.05), which then decreased (P&lt;0.01). While alfaxalone caused a ventral globe deviation that lasted from T\n                    <jats:sub>2<\/jats:sub>\n                    to T\n                    <jats:sub>10<\/jats:sub>\n                    (P&lt;0.05) and was fully recovered at T\n                    <jats:sub>30<\/jats:sub>\n                    , propofol induced a ventral globe deviation from T\n                    <jats:sub>2<\/jats:sub>\n                    to T\n                    <jats:sub>5<\/jats:sub>\n                    (P&lt;0.05), being restored at T\n                    <jats:sub>20<\/jats:sub>\n                    . These results suggest that both alfaxalone and propofol can be safely used for intraocular surgery, as they significantly reduce IOP. Furthermore, anaesthetic induction with propofol would be especially recommended for dogs with tear deficiencies.\n                  <\/jats:p>","DOI":"10.1136\/vr.102621","type":"journal-article","created":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T06:52:17Z","timestamp":1413528737000},"page":"73-73","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Alfaxalone versus propofol in dogs: a randomised trial to assess effects on peri\u2010induction tear production, intraocular pressure and globe position"],"prefix":"10.1002","volume":"176","author":[{"given":"Daniel","family":"Costa","sequence":"first","affiliation":[{"name":"Departament de Medicina i Cirurgia Animals Facultat de Veterin\u00e0ria Universitat Aut\u00f2noma de Barcelona Bellaterra Barcelona 08193 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Leiva","sequence":"additional","affiliation":[{"name":"Servei d'Oftalmologia de la Fundaci\u00f3 Hospital Cl\u00ednic Veterinari &amp; Departament de Medicina i Cirurgia Animals Facultat de Veterin\u00e0ria Universitat Aut\u00f2noma de Barcelona Bellaterra Barcelona 08193 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Moll","sequence":"additional","affiliation":[{"name":"Departament de Medicina i Cirurgia Animals Facultat de Veterin\u00e0ria Universitat Aut\u00f2noma de Barcelona Bellaterra Barcelona 08193 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adri\u00e0","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Departament de Medicina i Cirurgia Animals Facultat de Veterin\u00e0ria Universitat Aut\u00f2noma de Barcelona Bellaterra Barcelona 08193 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Servei d'Oftalmologia de la Fundaci\u00f3 Hospital Cl\u00ednic Veterinari &amp; Departament de Medicina i Cirurgia Animals Facultat de Veterin\u00e0ria Universitat Aut\u00f2noma de Barcelona Bellaterra Barcelona 08193 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Andaluz","sequence":"additional","affiliation":[{"name":"Departament de Medicina i Cirurgia Animals Facultat de Veterin\u00e0ria Universitat Aut\u00f2noma de Barcelona Bellaterra Barcelona 08193 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2008.00616.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2004.04041.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2011.03.017"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2011.00966.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03007632"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2000.00099.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-34-1-84"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-197701000-00011"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2005.00264.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2010.00762.x"},{"key":"e_1_2_5_12_1","first-page":"943","volume-title":"Ocular patients","author":"GROSS M. 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