{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T01:05:59Z","timestamp":1781831159720,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T00:00:00Z","timestamp":1423872000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>\n                    Frequencies of antimicrobial resistance were determined amongst 14,555 clinical\n                    <jats:italic>Staphylococcus intermedius<\/jats:italic>\n                    group (SIG) isolates from UK dogs and cats to estimate resistance trends and quantify the occurrence of meticillin\u2010resistant\n                    <jats:italic>Staphylococcus pseudintermedius<\/jats:italic>\n                    (MRSP). Reports from two diagnostic laboratories (13,313 general submissions, 1242 referral centre only submissions) were analysed retrospectively (2003\/2006\u20132012). MRSP were defined by phenotypic resistance to meticillin and concurrent broad \u03b2\u2010lactam resistance; a subset was confirmed genetically (SIG\u2010specific\n                    <jats:italic>nuc<\/jats:italic>\n                    and\n                    <jats:italic>mecA<\/jats:italic>\n                    ). Trends were analysed by Cochran\u2010Armitage test. Resistance remained below 10 per cent for cefalexin, amoxicillin\u2010clavulanic acid and the fluoroquinolones. Increasing resistance trends were seen in both laboratories for ampicillin\/amoxicillin (both P&lt;0.001), cefovecin (both P&lt;0.046) and enrofloxacin (both P&lt;0.02). Resistance to cefalexin increased over time in referral hospital isolates (P&lt;0.001) to clindamycin (P=0.01) and trimethoprim\u2010sulfamethoxazole (P=0.001) amongst general laboratory submissions. Overall, 106\u00a0MRSP were isolated (0.7 per cent of submissions) including 32 (2.6 per cent of submissions, all genetically confirmed) from the referral centre population (inter\u2010laboratory difference P&lt;0.001). Against a background of widely susceptible SIG isolates, a new trend of increasing resistance to important antimicrobials was identified overtime and the emergence of MRSP from UK clinical cases was confirmed. Attention to responsible use of antibacterial therapy in small animal practice is urgently needed.\n                  <\/jats:p>","DOI":"10.1136\/vr.102651","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T03:04:25Z","timestamp":1415329465000},"page":"172-172","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":42,"title":["Increasing antimicrobial resistance in clinical isolates of\n                    <i>Staphylococcus intermedius<\/i>\n                    group bacteria and emergence of MRSP in the UK"],"prefix":"10.1002","volume":"176","author":[{"given":"L.","family":"Beever","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Services Royal Veterinary College Hawkshead Lane, Hatfield North Mymms Hertfordshire AL9 7TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bond","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Services Royal Veterinary College Hawkshead Lane, Hatfield North Mymms Hertfordshire AL9 7TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Graham","sequence":"additional","affiliation":[{"name":"NationWide Laboratories 23 Mains Lane Poulton\u2010Le\u2010Fylde Lancashire FY6 7LJ UK"},{"name":"Faculty of Medicine &amp; Health Sciences Sutton Bonington Campus Sutton Bonington Leicestershire LE12 5RD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Epidemiology Economics and Public Health, Royal Veterinary College Hawkshead Lane, Hatfield North Mymms Hertfordshire AL9 7TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. H.","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Services Royal Veterinary College Hawkshead Lane, Hatfield North Mymms Hertfordshire AL9 7TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Loeffler","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Services Royal Veterinary College Hawkshead Lane, Hatfield North Mymms Hertfordshire AL9 7TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,14]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"ANONYMOUS. (2006) Summary of Product Characteristics. Convenia 80\u00a0mg\/ml powder and solvent for solution for injection for dogs and cats (revised June 2011) European Medicines Agency.www.ema.europa.eu\/. 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