{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:38:19Z","timestamp":1785497899533,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2015,12,5]],"date-time":"2015-12-05T00:00:00Z","timestamp":1449273600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>\n                    Alveolar echinococcosis (AE), a parasitic disease primarily of the liver caused by the larval stage of\n                    <jats:italic>Echinococcus multilocularis<\/jats:italic>\n                    , is highly endemic in Switzerland. In contrast to well\u2010established management protocols in people, little is known with regard to optimal treatment strategies in dogs. The objective of this study was to describe the clinical signs and diagnostic procedures in dogs with AE and to evaluate outcome following medical treatment alone or surgery and medical treatment. Of 23 putative AE cases between 2004 and 2014, 20 were classified as confirmed (n=18) or probable (n=2) AE, based on abdominal ultrasound, serology, cytology, histology and\/or PCR. Most dogs presented with abdominal distension in an advanced stage of disease. Dogs receiving specific treatment (radical or debulking surgery together with medical treatment, or medical treatment alone) survived longer than dogs left untreated, but no difference was found between treatment types. Survival at one year was associated with absence of free abdominal fluid, absence of abdominal distension and treatment of any type. However, dogs treated with debulking surgery all faced relapse. Findings of this study suggest that in AE\u2010affected dogs for which a therapeutic approach is regarded appropriate by owners and veterinarians, radical surgical resection and medical treatment or, if total resection is not possible, medical treatment alone should be considered. However, studies on larger numbers of dogs are necessary before definitive treatment recommendations can be made.\n                  <\/jats:p>","DOI":"10.1136\/vr.103470","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T22:43:50Z","timestamp":1446677030000},"page":"569-569","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":42,"title":["Clinical presentation, diagnosis, therapy and outcome of alveolar echinococcosis in dogs"],"prefix":"10.1002","volume":"177","author":[{"given":"M.","family":"Corsini","sequence":"first","affiliation":[{"name":"Vetsuisse Faculty Department of Clinical Veterinary Medicine Clinic for Small Animals, University of Bern L\u00e4nggassstrasse 128 Bern 3012 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Geissb\u00fchler","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty Department of Clinical Veterinary Medicine Clinical Radiology University of Bern L\u00e4nggassstrasse 128 Bern 3012 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Howard","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty Department of Clinical Veterinary Medicine Clinical Diagnostic Laboratory University of Bern L\u00e4nggassstrasse 124 Bern 3012 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Gottstein","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty Department of Infectious Diseases and Pathobiology Institute of Parasitology, University of Bern L\u00e4nggassstrasse 122 Bern 3012 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Spreng","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty Department of Clinical Veterinary Medicine Clinic for Small Animals, University of Bern L\u00e4nggassstrasse 128 Bern 3012 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. F.","family":"Frey","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty Department of Infectious Diseases and Pathobiology Institute of Parasitology, University of Bern L\u00e4nggassstrasse 122 Bern 3012 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.06.015"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.d4673"},{"key":"e_1_2_6_4_1","first-page":"300","article-title":"Alveol\u00e4re Echinokokkose bei einer Amerikanischen Bulldogge in Sachsen\u2010Anhalt \u2013 ein Fallbericht","volume":"6","author":"BEHRENS S.","year":"2011","journal-title":"Kleintiermedizin"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2005.11.053"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2012.00425.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2009.11.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-008-0392-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(01)00424-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333544"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1093\/oso\/9780192623805.003.0053","volume-title":"Zoonoses","author":"ECKERT J.","year":"1998"},{"key":"e_1_2_6_12_1","unstructured":"EUROPEAN SCIENTIFIC COUNSEL COMPANION ANIMAL PARASITES (ESCCAP). (2015) Worm control in dogs and cats. Guideline 01 2nd edition.www.esccap.ch\/2\u2010uploads\/praxis\/ESCCAP%20CH_GL%20Endo%20rev_d_def_200415.pdf. (accessed 1\u00a0Jun 2015)"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-9-159"},{"key":"e_1_2_6_14_1","first-page":"261","article-title":"Hunde als Finnentr\u00e4ger (Intermedi\u00e4rwirt) von Echinococcus multilocularis","volume":"35","author":"GEISEL O.","year":"1990","journal-title":"Kleintierpraxis"},{"key":"e_1_2_6_15_1","first-page":"267","article-title":"Pulmonary Echinococcus multilocularis metastasis in a dog","volume":"56","author":"GENDRON K.","year":"2015","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0450.1991.tb00858.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.31.2.373-376.1993"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2015.06.001"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2014063"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-34-4-309"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1024\/0036-7281.149.3.123","article-title":"Ein Fall von alveol\u00e4rer Echinococcose beim Hund: Haustiere als seltene Fehlzwischenwirte von Echinococcus multilocularis","volume":"149","author":"HEIER A.","year":"2007","journal-title":"Schweizer Archiv f\u00fcr Tierheilkunde"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4998"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2005.11.041"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2012.07.003"},{"key":"e_1_2_6_25_1","first-page":"408","article-title":"Letale alveol\u00e4re Echinokokkose bei einem Hund: Klinik und Pathologie","volume":"126","author":"MEYER A.","year":"2013","journal-title":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12210"},{"key":"e_1_2_6_27_1","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1080\/00015458.2007.11680128","article-title":"Alveolar hydatid disease: imaging findings and surgical approach","volume":"107","author":"PARSAK C. K.","year":"2007","journal-title":"Acta Chirurgica Belgica"},{"key":"e_1_2_6_28_1","first-page":"870","article-title":"Alveolar hydatid disease (Echinococcus multilocularis) in the liver of a Canadian dog in British Columbia, a newly endemic region","volume":"53","author":"PEREGRINE A. S.","year":"2012","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anicom.2012.12.002"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.02.018"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1987.36.576"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2004.04074.x"},{"key":"e_1_2_6_33_1","first-page":"435","article-title":"Finnen von Echinococcus multilocularis in der Unterhaut bei einem Hund","volume":"46","author":"SCHUSTER R.","year":"2001","journal-title":"Kleintierpraxis"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1306.061074"},{"key":"e_1_2_6_35_1","first-page":"551","article-title":"Hepatic alveolar hydatid disease (Echinococcus multilocularis) in a boxer dog from southern Ontario","volume":"55","author":"SKELDING A.","year":"2014","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2006.05.026"},{"key":"e_1_2_6_37_1","first-page":"343","article-title":"Subclinical alveolar echinococcosis in a dog initially showing clinical features of leptospirosis","volume":"41","author":"STEFFL M.","year":"2013","journal-title":"Tier\u00e4rztliche Praxis. Ausgabe K, Kleintiere\/Heimtiere"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.03.023"},{"key":"e_1_2_6_39_1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.vetpar.2012.03.024","article-title":"Echinococcus multilocularis in dogs from two French endemic areas: no evidence of infection but hazardous deworming practices","volume":"188","author":"UMHANG G.","year":"2012","journal-title":"Veterinary Parasitology"},{"key":"e_1_2_6_40_1","first-page":"231","article-title":"Guidelines for treatment of cystic and alveolar echinococcosis in humans","volume":"74","author":"WORLD HEALTH ORGANIZATION (WHO), INFORMAL WORKING GROUP ON ECHINOCOCCOSIS","year":"1996","journal-title":"Bulletin of the World Health Organization"}],"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1136%2Fvr.103470","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/vr.103470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T09:46:37Z","timestamp":1761558397000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1136\/vr.103470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":39,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1136\/vr.103470"],"URL":"https:\/\/doi.org\/10.1136\/vr.103470","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]}}}