{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T02:40:43Z","timestamp":1768444843437,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2015,12,5]],"date-time":"2015-12-05T00:00:00Z","timestamp":1449273600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>\n                    Physiological and biochemical variables in captive tigers (\n                    <jats:italic>Panthera tigris<\/jats:italic>\n                    ) immobilised with dexmedetomidine and ketamine or dexmedetomidine, midazolam and ketamine were evaluated. Thirty tigers received either dexmedetomidine (0.025\u00a0mg\/kg) and ketamine (3\u00a0mg\/kg) (group DK) or dexmedetomidine (0.0125\u00a0mg\/kg), midazolam (0.1\u00a0mg\/kg) and ketamine (3\u00a0mg\/kg) (group DMK). Heart rate, SPO\n                    <jats:sub>2<\/jats:sub>\n                    and blood pressure were measured at five\u2010minute intervals. Arterial pH, PO\n                    <jats:sub>2<\/jats:sub>\n                    , PCO\n                    <jats:sub>2<\/jats:sub>\n                    , glucose, K\n                    <jats:sup>+<\/jats:sup>\n                    and arterial and venous lactate were measured at 15 and 45\u00a0minutes after immobilisation. A generalised linear mixed model was used for statistical comparison. There was no difference within or between groups at any time point for any measured variable. Measured PO\n                    <jats:sub>2<\/jats:sub>\n                    was 73.2\u00b117.5\u00a0mm Hg and SPO\n                    <jats:sub>2<\/jats:sub>\n                    was 88.9\u00b110.8 per cent. Systolic, mean and diastolic blood pressures were 170.5\u00b148.4, 138.9\u00b141.8 and 121.8\u00b137.2\u00a0mm Hg, respectively. Venous lactate was higher than arterial lactate within groups at each time point. Seizure\u2010like behaviour was observed in 25 per cent of tigers in group DK but not in group DMK. The addition of midazolam into a protocol for immobilisation of tigers did not result in a difference in any of the measured variables but may have prevented the development of seizure\u2010like behaviour.\n                  <\/jats:p>","DOI":"10.1136\/vr.103526","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T22:54:06Z","timestamp":1449010446000},"page":"570-570","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Physiological and biochemical variables in captive tigers (\n                    <i>Panthera tigris<\/i>\n                    ) immobilised with dexmedetomidine and ketamine or dexmedetomidine, midazolam and ketamine"],"prefix":"10.1002","volume":"177","author":[{"given":"S. C.","family":"Clark\u2010Price","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Medicine College of Veterinary Medicine, University of Illinois 1008 W Hazelwood Drive, MC\u2010004 Urbana Illinois 61802 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. M.","family":"Lascola","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine College of Veterinary Medicine, University of Illinois 1008 W Hazelwood Drive, MC\u2010004 Urbana Illinois 61802 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Schaeffer","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine College of Veterinary Medicine, University of Illinois 1008 W Hazelwood Drive, MC\u2010004 Urbana Illinois 61802 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,5]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"23","article-title":"Evaluation of a xylazine\u2010ketmine hydrochloride combination in the cat","volume":"50","author":"ALLEN D. 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