{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:27:28Z","timestamp":1778279248700,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2016,5,14]],"date-time":"2016-05-14T00:00:00Z","timestamp":1463184000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>The aim of this study was to develop and evaluate a pharmacokinetic model\u2010driven infusion of propofol in premedicated cats. In a first step, propofol (10\u00a0mg\/kg) was administered intravenously over 60\u00a0seconds to induce anaesthesia for the elective neutering of seven healthy cats, premedicated intramuscularly with 0.3\u00a0mg\/kg methadone, 0.01\u00a0mg\/kg medetomidine and 2\u00a0mg\/kg ketamine. Venous blood samples were collected over 240\u00a0minutes, and propofol concentrations were measured via a validated high\u2010performance liquid chromatography assay. Selected pharmacokinetic parameters, determined by a three\u2010compartment open linear model, were entered into a computer\u2010controlled infusion pump (target\u2010controlled infusion\u20101 (TCI\u20101)). In a second step, TCI\u20101 was used to induce and maintain general anaesthesia in nine cats undergoing neutering. Predicted and measured plasma concentrations of propofol were compared at specific time points. In a third step, the pharmacokinetic parameters were modified according to the results from the use of TCI\u20101 and were evaluated again in six cats. For this TCI\u20102\u00a0group, the median values of median performance error and median absolute performance error were \u22121.85 per cent and 29.67 per cent, respectively, indicating that it performed adequately. Neither hypotension nor respiratory depression was observed during TCI\u20101 and TCI\u20102. Mean anaesthesia time and time to extubation in the TCI\u20102\u00a0group were 73.90 (\u00b120.29) and 8.04 (\u00b15.46) minutes, respectively.<\/jats:p>","DOI":"10.1136\/vr.103560","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T23:19:25Z","timestamp":1459811965000},"page":"503-503","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation and optimisation of propofol pharmacokinetic parameters in cats for target\u2010controlled infusion"],"prefix":"10.1002","volume":"178","author":[{"given":"A.","family":"Cattai","sequence":"first","affiliation":[{"name":"Department of Animal Medicine Production and Health Universit\u00e0 degli Studi di Padova Padua 35020 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Pilla","sequence":"additional","affiliation":[{"name":"AHP\u2010Animal Hospital Postojna\u00c2, 6230 Postojna, Slovenia Centro Veterinario di Diagnostica per Immagini Udine 0432 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Cagnardi","sequence":"additional","affiliation":[{"name":"Department of Health Animal Science and Food Safety Universit\u00e0 degli Studi di Milano Milan 20133 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zonca","sequence":"additional","affiliation":[{"name":"Department of Health Animal Science and Food Safety Universit\u00e0 degli Studi di Milano Milan 20133 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Franci","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine Production and Health Universit\u00e0 degli Studi di Padova Padua 35020 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/52.8.743"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.148.7.198"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2012.00722.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12034"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1365-2885.2008.01019.x","article-title":"A step towards effect\u2010site target\u2010controlled infusion with propofol in dogs: a ke0 for propofol","volume":"32","author":"BR\u00c0S S.","year":"2008","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12231"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1972.tb06864.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199506000-00003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200006000-00009"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200311000-00031"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1989.tb11333.x"},{"key":"e_1_2_7_13_1","first-page":"335","article-title":"Target controlled infusion: TCI","volume":"71","author":"GUARRACINO F.","year":"2005","journal-title":"Minerva Anestesiologica"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/51.7.579"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2003.64.913"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2012.62.2.113"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2001.62.1745"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2005.00251.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.240.4.404"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.223.1608"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1098-612X(03)00053-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst0011163"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2012.00773.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.157.24.766"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2011.07.002"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2005.00216.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.65.641"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.222.37"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2011.01.001"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X14558893"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199105000-00002"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1998.53s104.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200038020-00003"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01143186"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.243.6.844"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01117450"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.10.011"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2012.01377.x"}],"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1136%2Fvr.103560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/vr.103560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:39:19Z","timestamp":1761565159000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1136\/vr.103560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":37,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1136\/vr.103560"],"URL":"https:\/\/doi.org\/10.1136\/vr.103560","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5]]}}}