{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:32:04Z","timestamp":1787625124769,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T00:00:00Z","timestamp":1478908800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>Canine mast cell tumours (MCTs) are variable in their biological behaviour and treatment decisions depend heavily on the histopathological grade. Biomarkers such as neutrophil to lymphocyte ratio (NLR) and albumin to globulin ratio are used to predict the biological behaviour of human neoplasms, but have not been widely studied in dogs. A retrospective analysis identified 62 cases of gross MCT (14 high\u2010grade, 48 low\u2010grade tumours). Median NLR was significantly different between high\u2010 and low\u2010grade MCT and tumours at different locations. A multivariable model identified increasing NLR (OR 2.0) and age (OR 1.7) to be associated with an increased risk of high\u2010grade MCT. Receiver operating characteristic curve analysis identified an NLR threshold value of 5.67 (sensitivity 85.7 per cent; specificity 54.2 per cent) for predicting a high\u2010grade MCT. An NLR threshold of 5.67 could be useful alongside existing tools (appearance, location, etc.) to help to predict the grade of MCT. With further validation, this biomarker could be used to guide clinical decisions before obtaining a histopathological diagnosis.<\/jats:p>","DOI":"10.1136\/vr.103650","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T22:59:02Z","timestamp":1474412342000},"page":"491-491","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Use of neutrophil to lymphocyte ratio for predicting histopathological grade of canine mast cell tumours"],"prefix":"10.1002","volume":"179","author":[{"given":"M. J.","family":"Macfarlane","sequence":"first","affiliation":[{"name":"University of Glasgow, School of Veterinary Medicine Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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