{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:02:08Z","timestamp":1761663728785,"version":"build-2065373602"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,6]],"date-time":"2018-01-06T00:00:00Z","timestamp":1515196800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>There is little peer\u2010reviewed research assessing therapeutic effectiveness in canine eye disease. Current treatments used in first opinion and ophthalmology referral practices are also somewhat poorly documented. The aim of this study was to investigate the current management of canine keratoconjunctivitis sicca (KCS) and acute primary angle\u2010closure glaucoma (PACG) by veterinary surgeons. Questionnaires using clinical vignettes were administered to a cross section of general practitioners (\u2018GPs\u2019) and veterinarians engaged in or training for postgraduate ophthalmology practice (\u2018PGs\u2019). Similar treatment recommendations for KCS (topical cyclosporine, lubricant, antibiotic) were given by both groups of veterinarians with the single exception of increased topical antibiotic use by GPs. Treatment of acute glaucoma diverged between groups: PGs were much more likely to recommend topical prostaglandin analogues and a wider array of both topical and systemic treatments were recommended by both groups. Systemic ocular hypotensive agents were suggested infrequently. Our results suggest that treatments may vary substantially in ocular conditions, particularly in conditions for which neither guidelines nor high\u2010quality evidence exists. This study highlights the need for novel strategies to address evidence gaps in veterinary medicine, as well as for better evaluation and dissemination of current treatment experience.<\/jats:p>","DOI":"10.1136\/vr.104390","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T20:22:09Z","timestamp":1514060529000},"page":"21-21","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Use of clinical vignette questionnaires to investigate the variation in management of keratoconjunctivitis sicca and acute glaucoma in dogs"],"prefix":"10.1002","volume":"182","author":[{"given":"Constance N.","family":"White","sequence":"first","affiliation":[{"name":"Fremont Veterinary Clinic Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J.","family":"Downes","sequence":"additional","affiliation":[{"name":"Centre for Applied Health Economics, School of Medicine, Griffith University Meadowbrook Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth","family":"Jones","sequence":"additional","affiliation":[{"name":"Park Veterinary Group Glenfield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne","family":"Wigfall","sequence":"additional","affiliation":[{"name":"Dairy Flat Veterinary Clinic Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel S.","family":"Dean","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Science, Centre for Evidence\u2010based Veterinary Medicine, University of Nottingham Loughborough UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4893-6583","authenticated-orcid":false,"given":"Marnie L","family":"Brennan","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Science, Centre for Evidence\u2010based Veterinary Medicine, University of Nottingham Loughborough UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,6]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"668","article-title":"Coping with blindness: a survey of 50 blind dogs","volume":"123","author":"Chester Z","year":"1988","journal-title":"Vet Rec"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2004.04006.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2006.00185.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.24.1.18"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53592-4.00002-5"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12225"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0392.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13841"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2010.00889.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-10-200411160-00008"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1062860605274520"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00952-8"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-9-128"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.101745"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.102818"},{"key":"e_1_2_10_17_1","first-page":"pp 292","article-title":"Principles of biostatistics","author":"Pagano M","year":"2000","journal-title":"Duxbury Pacific Grove, CA."},{"key":"e_1_2_10_18_1","article-title":"Canine diabetes mellitus; monitoring and survival in first opinion practice. 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