{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T14:14:36Z","timestamp":1768745676930,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,7,28]],"date-time":"2018-07-28T00:00:00Z","timestamp":1532736000000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Estonian Ministry of Rural Affairs"},{"DOI":"10.13039\/501100003510","name":"Estonian Ministry of Education and Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003510","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>Cytological endometritis (CYTO) is a uterine inflammation characterised by the percentage of polymorphonuclear neutrophils in endometrial cytology. This observational study evaluated the association of blood plasma insulin\u2010like growth factor\u20101 (IGF\u20101) and insulin concentrations at \u22122 weeks prepartum, +1\u2009week and +3\u2009weeks postpartum with the development of CYTO in 119 multiparous Holstein cows. Overall CYTO prevalence was 30.3 per cent. Multivariable logistic regression model revealed the odds of developing CYTO were 3.54 times (P=0.018) greater in cows with week \u22122 prepartum IGF\u20101 concentrations less than 74.6\u2009ng\/ml and 4.41 times (P=0.004) higher in cows with week +1\u2009postpartum IGF\u20101 concentrations less than 13.2\u2009ng\/ml than the odds of this health outcome in cows with IGF\u20101 concentrations at least 74.6\u2009and13.2\u2009ng\/ml, respectively. Additionally, cows with body condition score (BCS) up to 2.75 at week \u22122 prepartum and cows experiencing calving\u2010related disorders and\/or ill health had higher risk for CYTO compared with cows with BCS=3.50\u20133.75 (OR=6.8, P=0.049) and cows without health complications (OR=3.1, P=0.030). Insulin was not a significant predictor for CYTO in the model. Our findings provide further evidence that reduced dairy cow fertility associated with low plasma concentrations of IGF\u20101 is in part mediated through the inflammatory status of the uterus.<\/jats:p>","DOI":"10.1136\/vr.104640","type":"journal-article","created":{"date-parts":[[2018,4,21]],"date-time":"2018-04-21T12:20:28Z","timestamp":1524313228000},"page":"126-126","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Relationships between plasma insulin\u2010like growth factor\u20101 and insulin concentrations in multiparous dairy cows with cytological endometritis"],"prefix":"10.1002","volume":"183","author":[{"given":"Merle","family":"Valdmann","sequence":"first","affiliation":[{"name":"Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences Tartu 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