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The aim of this study was to examine the efficacy of two intravenous analgesic regimens, preoperative administration of meloxicam and tramadol, or meloxicam alone, in free\u2010roaming dogs undergoing sterilisation. A total of 125 dogs were included, with 64 dogs in the meloxicam\u2010tramadol arm and 61 dogs in the meloxicam\u2010only arm in a non\u2010inferiority study design. Pain levels in sterilisation surgery patients were assessed at four time points after surgery using the Colorado State University Canine Acute Pain Scale, a Visual Analogue Scale and a modified version of the Glasgow Composite Measure Pain Scale \u2013 Short Form. Non\u2010inferiority was supported for each of the main scoring outcomes using non\u2010inferiority margins of 0.5, 5 and 0.8, respectively. One dog from the meloxicam\u2010tramadol group and four dogs in the meloxicam\u2010only arm required rescue analgesia, with no difference between groups (P=0.21).The study demonstrated that meloxicam was effective in controlling postoperative pain in a high proportion of dogs. 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