{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:40:16Z","timestamp":1785577216477,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2019,3,30]],"date-time":"2019-03-30T00:00:00Z","timestamp":1553904000000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>To investigate the clinical pharmacokinetics and pharmacodynamics of intravenous alfaxalone in young Thoroughbred horses, seven Thoroughbred horses were randomly anaesthetised twice with either 1 or 2\u2009mg\/kg of intravenous alfaxalone after premedication with medetomidine (6\u2009\u00b5g\/kg intravenous) and midazolam (20\u2009\u00b5g\/kg intravenous). Blood samples were collected at predetermined time points up to two\u2009hours after administration. Plasma alfaxalone concentrations were quantified by a liquid chromatography tandem\u2010mass spectrometry method and analysed by non\u2010compartmental pharmacokinetic analysis. Induction and recovery qualities were good to excellent for both doses. Recovery time for the 2\u2009mg\/kg (median 90\u2009minutes) was significantly longer than that for the 1\u2009mg\/kg (median 50\u2009minutes). Respiratory rate for the 2\u2009mg\/kg was significantly lower than that for the 1\u2009mg\/kg, resulting in hypoxaemia. The median (range) elimination half\u2010life, total clearance and volume of distribution were 58.2 (42.3\u201370.7)\u2009minutes, 11.6 (10.3\u201314.5)\u2009ml\/minute\/kg and 0.8 (0.7\u20130.9)\u2009l\/kg for the 1\u2009mg\/kg and 59.8 (47.5\u201368.0)\u2009minutes, 14.7 (12.1\u201316.0)\u2009ml\/minute\/kg and 0.9 (0.9\u20131.2)\u2009l\/kg for the 2\u2009mg\/kg, respectively. Alfaxalone is rapidly eliminated from the plasma in young Thoroughbred horses. Respiratory depression should be especially noted when alfaxalone is used in clinical practice.<\/jats:p>","DOI":"10.1136\/vr.105070","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T15:24:11Z","timestamp":1553873051000},"page":"411-411","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical pharmacokinetics and pharmacodynamics of intravenous alfaxalone in young Thoroughbred horses premedicated with medetomidine and midazolam"],"prefix":"10.1002","volume":"184","author":[{"given":"Ai","family":"Wakuno","sequence":"first","affiliation":[{"name":"Miho Training Center Racehorse Clinic, JRA Inashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Aoki","sequence":"additional","affiliation":[{"name":"Miho Training Center Racehorse Clinic, JRA Inashiki 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