{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:36:48Z","timestamp":1773679008238,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"25","license":[{"start":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T00:00:00Z","timestamp":1561161600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"PetSavers"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomised non\u2010blinded non\u2010inferiority trial was conducted to determine whether treatment with an unfractionated regimen of oral prednisolone was inferior to a fractionated regimen for dogs with primary immune\u2010mediated haemolytic anaemia. Dogs received the same total daily dose of prednisolone as unfractionated (group 1, starting at 4\u2009mg\/kg orally once daily) or fractionated (group 2, starting at 2\u2009mg\/kg orally twice daily) doses. Questionnaires were administered to owners to assess adverse effects and quality of life (QoL). End points included survival to eight weeks, and changes in QoL and clinicopathological parameters over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010nine dogs were enrolled in the study, of which 5 were withdrawn and 17 were assigned to each group. The number of cases recruited was insufficient to determine whether unfractionated treatment was inferior to fractionated. Total serum bilirubin decreased more rapidly in dogs in group 2, whereas polydipsia improved more rapidly in group 1. Blood pressure and score for polyuria were higher in dogs in group 2 over time, whereas lymphocyte concentration was lower.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Administration of the same total daily dose of prednisolone as an unfractionated dose resulted in fewer adverse effects but the effect on survival could not be assessed in this study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/vr.105104","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T17:19:12Z","timestamp":1556817552000},"page":"771-771","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Randomised controlled trial of fractionated and unfractionated prednisolone regimens for dogs with immune\u2010mediated haemolytic anaemia"],"prefix":"10.1002","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7988-9997","authenticated-orcid":false,"given":"James W","family":"Swann","sequence":"first","affiliation":[{"name":"Kennedy Institute of Rheumatology, University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balazs","family":"Szladovits","sequence":"additional","affiliation":[{"name":"Pathology and Pathogen Biology Royal Veterinary College Hatfield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna J","family":"Threlfall","sequence":"additional","affiliation":[{"name":"Small Animal Internal Medicine Davies Veterinary Specialists Higham Gobion UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4133-9487","authenticated-orcid":false,"given":"Oliver A","family":"Garden","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Mei","family":"Chang","sequence":"additional","affiliation":[{"name":"Research Support Office Royal Veterinary College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B","family":"Church","sequence":"additional","affiliation":[{"name":"Queen Mother Hospital for Animals, Royal Veterinary College Hatfield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4830-7610","authenticated-orcid":false,"given":"Barbara","family":"Glanemann","sequence":"additional","affiliation":[{"name":"Queen Mother Hospital for Animals, Royal Veterinary College Hatfield 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