{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T11:01:42Z","timestamp":1761649302202,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Melatonin is a hormone produced and secreted primarily by the pineal gland and mainly metabolised in the liver. Increased melatonin concentrations have been reported in human cirrhosis and hepatic encephalopathy (HE), a syndrome of neurological dysfunction. The pathogenesis of canine HE is incompletely understood. Melatonin has been hypothesised as a contributor to the development of HE. The aim of this study was to investigate whether serum melatonin concentrations are increased in canine congenital portosystemic shunting (cPSS), with and without HE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records were retrospectively reviewed, for which archived (\u221280\u00b0C) serum samples were available. A canine competitive ELISA was used to measure melatonin in two cohorts: dogs with a final diagnosis of cPSS (n=23) with and without clinical signs of HE, and healthy dogs (n=15).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Melatonin concentrations were not significantly different (P=0.81) between healthy controls (median 27.2\u2009pg\/mL, range 19.8\u2013161.5\u2009pg\/mL) and dogs with cPSS (median 25.7\u2009pg\/mL, range 18.5\u2013244.9\u2009pg\/mL). Serum melatonin did not differ between cPSS patients with and without clinical signs of HE (P&gt;0.99). No correlation was found between serum melatonin and blood ammonia (Spearman rank correlation coefficient,\n                      <jats:italic>\n                        r\n                        <jats:sub>s<\/jats:sub>\n                      <\/jats:italic>\n                      =\u22120.41, P=0.08).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum melatonin is not increased in canine cPSS with and without HE. We found no evidence that altered melatonin metabolism plays a role in the pathogenesis of cPSS\u2010associated HE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/vr.105245","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T17:25:30Z","timestamp":1579800330000},"update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Serum melatonin in dogs with congenital portosystemic shunting, with and without hepatic encephalopathy"],"prefix":"10.1002","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8123-4612","authenticated-orcid":false,"given":"Marisa da Fonseca","family":"Ferreira","sequence":"first","affiliation":[{"name":"Hospital for Small Animals The Royal (Dick) School of Veterinary Studies The University of Edinburgh Roslin Midlothian 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