{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:35:06Z","timestamp":1790667306720,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T00:00:00Z","timestamp":1556323200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000277","name":"Department for Environment, Food and Rural Affairs, UK Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000277","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Hantaviruses are maintained by mammalian hosts, such as rodents, and are shed in their excretions. Clinical disease can occur in humans from spillover infection. Brown rats (\n                      <jats:italic>Rattus norvegicus)<\/jats:italic>\n                      are the globally distributed reservoir host of Seoul virus (SEOV). Human cases of SEOV\u2010associated haemorrhagic fever with renal syndrome (SEOV\u2010HFRS)have been reported in Great Britain (GB) since 1977.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Brown rats (n=68) were trapped from a variety of peridomestic locations, with a focus on pig farms. Kidney and lung tissues were tested for viral RNA using a pan\u2010hantavirus RT\u2010PCR assay followed by Sanger sequencing and analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SEOV RNA was detected in 19 per cent (13\/68, 95%\u2009CI 11 to 30) of rats and all sequences fell within SEOV lineage 9. Twelve sequences were highly similar to each other and to the previously reported GB Humber strain of SEOV (98 per cent). One rat SEOV sequence was more distant. The SEOV prevalence in rats from pig farms was significantly greater (p=0.047) than other sites sampled. No significant sex or age differences were observed among positive and negative rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The results from this study suggest that SEOV could be widespread in wild rats in GB and therefore pose a potential risk to public health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/vr.105249","type":"journal-article","created":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T17:20:26Z","timestamp":1554484826000},"page":"525-525","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Detection of Seoul virus in wild brown rats (\n                    <i>Rattus norvegicus<\/i>\n                    ) from pig farms in Northern England"],"prefix":"10.1002","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2225-6026","authenticated-orcid":false,"given":"Ellen G","family":"Murphy","sequence":"first","affiliation":[{"name":"HPRU EZI, Institute of Infection and Global Health (IGH), University of Liverpool School of Life Sciences Neston Cheshire UK"},{"name":"Institute of Infection and Global Health, University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola J","family":"Williams","sequence":"additional","affiliation":[{"name":"HPRU EZI, Institute of Infection and Global Health (IGH), University of Liverpool School of Life Sciences Neston Cheshire UK"},{"name":"Institute of Infection and Global Health, University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Bennett","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Science, University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Jennings","sequence":"additional","affiliation":[{"name":"Wildlife Zoonoses and Vector\u2010Borne Disease Research Group Animal and Plant Health Agency Addlestone UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Chantrey","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology School of Life Sciences, Institute of Veterinary Science, University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine M","family":"McElhinney","sequence":"additional","affiliation":[{"name":"HPRU EZI, Institute of Infection and Global Health (IGH), University of Liverpool School of Life Sciences Neston Cheshire UK"},{"name":"Wildlife Zoonoses and Vector\u2010Borne Disease Research Group Animal and Plant Health Agency Addlestone UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,27]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"ICTV.International Committee on Taxonomy of Viruses (ICTV) [Internet]. Virus Taxonomy: 2018 Release 2018.https:\/\/talk.ictvonline.org\/taxonomy\/(cited 15 Jan 2019)."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.3.1321-1331.2000"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2013.12.035"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-49-7-587"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2015.02.010"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.08.033"},{"key":"e_1_2_12_8_1","unstructured":"CDC.CDC \u2010 Hemorrhagic Fever with Renal Syndrome (HFRS) \u2010 Hantavirus [Internet].2018https:\/\/www.cdc.gov\/hantavirus\/hfrs\/index.html(cited 15 Jan 2019)."},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1901.111587"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2013.12.036"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7458409"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(86)93533-4"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268817001819"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.i817"},{"key":"e_1_2_12_15_1","unstructured":"PFMA.Pet Population Statistics [Internet].2018.https:\/\/www.pfma.org.uk\/pet\u2010population\u20102018(cited 15 Jan 2019)."},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268817001480"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-205529"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1205.051487"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msw054"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404206101"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.2807\/ese.18.01.20344-en"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10446"},{"key":"e_1_2_12_23_1","article-title":"Targeted surveillance for Ljungan virus and Hantaviruses in UK rodents","author":"Pounder KC","year":"2013","journal-title":"University of Liverpool"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/v6020524"},{"key":"e_1_2_12_25_1","article-title":"Mammals of the British Isles: Handbook","author":"Harris S","year":"2008","journal-title":"The Mammal Society"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2004.70.310"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0809.010537"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.65.57"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2005.06.003"},{"key":"e_1_2_12_30_1","first-page":"557","article-title":"In utero and mammary transfer of hantavirus antibody from dams to infant rats","volume":"43","author":"Dohmae K","year":"1993","journal-title":"Lab Anim Sci"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01933-14"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00725-11"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2412.180229"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2306.160927"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2406.172044"}],"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1136%2Fvr.105249","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/vr.105249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T09:27:38Z","timestamp":1761643658000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1136\/vr.105249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":34,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1136\/vr.105249"],"URL":"https:\/\/doi.org\/10.1136\/vr.105249","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4]]}}}