{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T07:14:17Z","timestamp":1761635657126,"version":"build-2065373602"},"reference-count":38,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T00:00:00Z","timestamp":1576886400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria of Spain","award":["RTA2015-00043-C02-02"],"award-info":[{"award-number":["RTA2015-00043-C02-02"]}]},{"name":"Spanish Ministry of Science, Innovation and Universities","award":["DI-15-08110","IJCI-2015-24805"],"award-info":[{"award-number":["DI-15-08110","IJCI-2015-24805"]}]},{"name":"Ministerio de Econom\u00eda, Industria y Competitividad of Spain","award":["RTC-2016-4746-2"],"award-info":[{"award-number":["RTC-2016-4746-2"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      There is evidence for a link between vitamin D deficiency and active tuberculosis (TB). In human beings, several trials have evaluated the role of vitamin D supplementation in TB treatment with conflicting results. However, the role of vitamin D supplementation in animal TB control has received less attention. The authors evaluated the bene\ufb01t of vitamin D supplementation for preventing mycobacterial infection or reducing TB lesions (TBL) in a controlled trial with goats naturally exposed to\n                      <jats:italic>Mycobacterium caprae<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Two groups of goats, a vitamin D\u2010supplemented group and a non\u2010supplemented control group, were housed for 10 months in direct contact with\n                      <jats:italic>M caprae<\/jats:italic>\n                      \u2010infected adult goats. Upon contact with the infected adult goats, all animals were TB\u2010tested every two months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No experimental evidence of a protective effect of vitamin D supplementation based on\n                      <jats:italic>M caprae<\/jats:italic>\n                      culture prevalence, TBL prevalence, median TBL score or the proportion of single versus multiple organs presenting TBL was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results indicate that, in the conditions used in this study, vitamin D supplementation in goats does not reduce TB infection risk nor the diffusion and severity of TBL. In addition, vitamin D\u2010supplemented goats presented hyperphosphataemia and renal injury with calcifications suggestive of vitamin D intoxication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/vr.105411","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T17:24:30Z","timestamp":1572974670000},"page":"759-759","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Hypervitaminosis D has no positive effects on goat tuberculosis and may cause chronic renal lesions"],"prefix":"10.1002","volume":"185","author":[{"given":"Maria Angeles","family":"Risalde","sequence":"first","affiliation":[{"name":"Department of Comparative Pathology University of C\u00f3rdoba\u2010Agrifood Campus of International Excellence (ceiA3) Cordoba Spain"},{"name":"Infectious Diseases Unit Instituto Maimonides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC). 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