{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T11:22:14Z","timestamp":1761650534631,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T00:00:00Z","timestamp":1587600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000277","name":"Department for Environment, Food and Rural Affairs, UK Government","doi-asserted-by":"publisher","award":["ED1600"],"award-info":[{"award-number":["ED1600"]}],"id":[{"id":"10.13039\/501100000277","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002142","name":"Animal Health and Veterinary Laboratories Agency","doi-asserted-by":"publisher","award":["ED1600"],"award-info":[{"award-number":["ED1600"]}],"id":[{"id":"10.13039\/501100002142","id-type":"DOI","asserted-by":"publisher"}]},{"name":"This work was funded by the Veterinary Medicines Directorate under VMD grant number VM0533.","award":["VM0533"],"award-info":[{"award-number":["VM0533"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The beta\u2010lactamase enzyme OXA\u201048 has spread widely in recent years in Enterobacteriaceae associated with man, disseminated primarily on incompatibility group L\/M plasmids. OXA\u201048 confers resistance to carbapenems, important antimicrobials for treating highly resistant bacterial infections in humans. This enzyme has rarely been detected in bacteria from animals. Furthermore, the use of carbapenem compounds is not permitted in food\u2010producing animals in Europe and to our knowledge has not been reported in food\u2010producing animals globally.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Bacterial isolates from lesions in stranded, free\u2010living, juvenile common seals (\n                      <jats:italic>Phoca vitulina<\/jats:italic>\n                      ) were identified. Antimicrobial susceptibility testing and whole genome sequencing analysis were used to characterise antimicrobial resistance genes carried by the bacteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Here, we report the detection of\n                      <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                      subspecies\n                      <jats:italic>pneumoniae<\/jats:italic>\n                      carrying the\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>OXA\u201048<\/jats:sub>\n                      gene on an incompatibility group L\/M plasmid from an infection in a common seal.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Evidence is accruing that marine mammals may be infected with bacteria originating from anthropogenic sources, such as human sewage, contaminating the environment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/vr.105440","type":"journal-article","created":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T17:16:33Z","timestamp":1587662193000},"page":"154-154","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Resistance to carbapenems and other antibiotics in\n                    <i>Klebsiella pneumoniae<\/i>\n                    found in seals indicates anthropogenic pollution"],"prefix":"10.1002","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7521-8923","authenticated-orcid":false,"given":"James Paul","family":"Duff","sequence":"first","affiliation":[{"name":"Animal Plant and Health Agency (APHA) Diseases of Wildlife Scheme APHA Penrith Veterinary Investigation Centre Penrith 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