{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T09:38:27Z","timestamp":1783762707352,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T00:00:00Z","timestamp":1578009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Petsavers"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There are limited published data on the analgesic efficacy of paracetamol\/codeine in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective, randomised, blinded, positive\u2010controlled clinical trial with 70 dogs (paracetamol\/codeine, n=46; meloxicam, n=24) undergoing surgery. Drugs were administered orally 2 hours before and for 48\u2009hours after surgery at the licensed dose. Anaesthesia was standardised. Dogs received buprenorphine 6 hourly for the first 24\u2009hours after surgery. Outcome assessments were made pretrial and at regular intervals up to 48\u2009hours after extubation and comprised the Glasgow Composite Measure Pain Score\u2010Short Form, visual analogue scale for sedation and inflammation and mechanical nociceptive threshold (MNT). Non\u2010inferiority of paracetamol\/codeine compared with meloxicam was defined using a non\u2010inferiority margin (\u0394) against the 95 per cent confidence interval of the difference between the treatment means.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pain scores were low in both treatment groups. With the exception of MNT all upper 95 per cent confidence intervals for the differences between outcome variable treatment means were within +\u0394 for each variable, establishing non\u2010inferiority for each outcome variable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Paracetamol\/codeine is a useful perioperative analgesic that within the context of the perioperative analgesia regimen studied (methadone premedication, buprenorphine for the first 24\u2009hours after surgery) shows non\u2010inferiority to the NSAID meloxicam.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/vr.105487","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T17:15:29Z","timestamp":1578071729000},"update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Comparing paracetamol\/codeine and meloxicam for postoperative analgesia in dogs: a non\u2010inferiority trial"],"prefix":"10.1002","volume":"187","author":[{"given":"Mariana","family":"Pacheco","sequence":"first","affiliation":[{"name":"Bristol Veterinary School University of Bristol Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby G","family":"Knowles","sequence":"additional","affiliation":[{"name":"Bristol Veterinary School University of Bristol Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Hunt","sequence":"additional","affiliation":[{"name":"Cave Veterinary Specialists Wellington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louisa S","family":"Slingsby","sequence":"additional","affiliation":[{"name":"Bristol Veterinary School University of Bristol Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polly M","family":"Taylor","sequence":"additional","affiliation":[{"name":"Taylor Monroe Ely UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0456-5159","authenticated-orcid":false,"given":"Joanna C","family":"Murrell","sequence":"additional","affiliation":[{"name":"Bristol Veterinary School University of Bristol Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,3]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u20102995.2005.00207.x"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2012.01.003"},{"key":"e_1_2_11_4_2","first-page":"11","article-title":"Paracetamol: mechanism of action, applications and safety concern","volume":"71","author":"J\u00f3\u017awiak\u2010Bebenista M","year":"2014","journal-title":"Acta Pol Pharm"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109592.2008.02764.x"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012748"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2013.04.007"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1090\u20103801(97)90103\u20108"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.72.2.184"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.11\u20100529"},{"key":"e_1_2_11_11_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1017\/S096272860003178X","article-title":"Development of the short\u2010form Glasgow composite measure pain scale (CMPS\u2013SF) and derivation of an analgesic intervention score","volume":"16","author":"Reid J","year":"2007","journal-title":"Anim Welfare"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/375421"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606\u2010010\u20101513\u20108"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.162.13.403"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u20101676.2011.00786.x"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12505567"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304\u20103959(97)00141\u20103"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/rvsc.2001.0467"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12103"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.102834"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12917\u2010017\u20101027\u20102"}],"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/vr.105487","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1136\/vr.105487","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1136%2Fvr.105487","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/vr.105487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:06:08Z","timestamp":1761566768000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1136\/vr.105487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,3]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1136\/vr.105487"],"URL":"https:\/\/doi.org\/10.1136\/vr.105487","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,3]]}}}