{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:06:09Z","timestamp":1782227169931,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To describe the efficacy of four\u2010layer porcine small intestinal submucosa (Vetrix BioSIS plus+) as single scaffold for the treatment of deep corneal lesions in dogs and cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>10 dogs and 3 cats with deep or full thickness corneal defects were treated surgically with BioSIS plus graft. Corneal transparency scores and vision were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Lesions in dogs were four perforations, three descemetoceles, two limbal melanocytomas and one deep corneal ulcer. In cats, there were one limbal melanocytoma and two perforations. The average length of the follow\u2010up was 86\u2009days. In all, 12 out of 13 eyes treated were visual at last recheck (92.3 per cent). The scars were mild eight cases (66.7 per cent), but denser in four cases (33.4 per cent). Complication were partial collagenolysis in three cases (25 per cent), which resolved with medical therapy, mild corneal pigmentation in one case (8.4 per cent) and anterior synechia in one case (8.4 per cent). One case experienced severe collagenolysis and was enucleated 21\u2009days postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Four\u2010layer porcine SIS graft was successfully used for surgical treatment of deep corneal lesions in selected corneal diseases in a small series of dogs and cats, with good results in terms of mechanic support and corneal transparency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/vr.105513","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T17:19:21Z","timestamp":1579022361000},"update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Use of four\u2010layer porcine small intestinal submucosa alone as a scaffold for the treatment of deep corneal defects in dogs and cats: preliminary results"],"prefix":"10.1002","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0636-1232","authenticated-orcid":false,"given":"Laura","family":"Barachetti","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine University of Milan Milan Italy"},{"name":"Dipartimento di Oftalmologia Istituto Veterinario di Novara Granozzo con Monticello Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Zanni","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science and Public Health University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damiano","family":"Stefanello","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Rampazzo","sequence":"additional","affiliation":[{"name":"Equine Department Universitat Zurich Vetsuisse\u2010Fakultat Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"641","article-title":"Conjunctival pedicle graft in the treatment of corneal ulcers in the dog and cat","volume":"23","author":"Hakanson N","year":"1987","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_9_3_1","first-page":"976","volume-title":"Disease and surgery of canine cornea andsclera","author":"Gelatt KN","year":"2013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(97)50104-5"},{"key":"e_1_2_9_5_1","first-page":"270","article-title":"Lamellar corneal\u2010scleral transposition","volume":"9","author":"Parshall C","year":"1973","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_9_6_1","first-page":"69","article-title":"Tarsoconjunctival island graft for the treatment of deep corneal ulcers, desmetocoeles, and perforations in 35 dogs and 6 cats","volume":"3","author":"Scagliotti RH","year":"1988","journal-title":"Semin Vet Med Surg"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1989.195.04.469"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1999.00084.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12392"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2005.00405.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2006.00480.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2009.00741.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2010.00821.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1999.00052.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12047"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12193"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12326"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12240"},{"key":"e_1_2_9_19_1","unstructured":"2018 The 49Th Annual Scientific Meeting Of The American College Of Veterinary Ophthalmologists Minneapolis Minnesota EG Da Silva Preliminary evaluation of a bio\u2010engineered porcine cornea in the treatment of deep corneal defects in dogs. 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