{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T01:04:24Z","timestamp":1775005464836,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This retrospective study assessed the onset and duration of the neuromuscular block (NMB) induced by cis\u2010atracurium 0.15\u2009mg\/kg intravenously with and without fentanyl or lidocaine infusions in 45 isoflurane\u2010anaesthetised dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Dogs with neuromuscular function assessed by a calibrated train\u2010of\u2010four (TOF) monitor with stimulation (every 13\u2009s) of the peroneal nerve were included. The onset and duration of the NMB were defined as the time from cis\u2010atracurium administration until TOF=0\u2009and the time during TOF=0 display, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The NMB onset was shorter during fentanyl (mean\u00b1sd) (1.9\u00b10.7\u2009minutes; P=0.0042) and lidocaine (2.0\u00b10.7\u2009minutes; P=0.0154) compared with control (2.9\u00b10.8\u2009minutes). The NMB duration was shorter in the fentanyl (27.5\u00b17.3\u2009minutes; P=0.0491), but not in the lidocaine group (32.3\u00b16.9\u2009minutes; P=0.0790), compared with control (33.7\u00b19.1\u2009minutes). The NMB onset was poorly but significantly correlated with the dose of fentanyl and lidocaine administered before cis\u2010atracurium (r=\u22120.3396; P=0.0225). The fentanyl and lidocaine groups received more crystalloid and colloid boluses than the control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fentanyl and lidocaine shortened the NMB onset and the former decreased the NMB duration. Further prospective studies are required to clarify whether this was associated with an indirect decrease in blood pressure or a direct interaction between cis\u2010atracurium and fentanyl and lidocaine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/vr.105522","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T17:25:29Z","timestamp":1579800329000},"update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Onset and duration of cis\u2010atracurium neuromuscular block during fentanyl and lidocaine infusions in isoflurane\u2010anaesthetised dogs"],"prefix":"10.1002","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2200-4355","authenticated-orcid":false,"given":"Keila K","family":"Ida","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Faculty of Veterinary Medicine University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Sophie","family":"Van\u2010Wijnsberghe","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Faculty of Veterinary Medicine University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandru","family":"Tutunaru","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Faculty of Veterinary Medicine University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Limpens","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Faculty of Veterinary Medicine University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lie","family":"Sauvage","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Faculty of Veterinary Medicine University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Serteyn","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Faculty of Veterinary Medicine University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Sandersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Faculty of Veterinary Medicine University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,23]]},"reference":[{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-2987.2001.00045.x"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen308"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2009.01078.x"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12109"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.22233\/9781910443231.16"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/IJCIIS.IJCIIS_35_16"},{"key":"e_1_2_12_8_2","first-page":"880","article-title":"Pretreatment with lidocaine accelerates onset of vecuronium\u2010induced neuromuscular blockade","volume":"51","author":"Nonaka A","year":"2002","journal-title":"Masui"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-70942005000400001"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-7094(09)70097-2"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-865020160070000009"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1990.tb12064.x"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90084-1"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199509000-00013"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.31037"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-011-1270-9"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.229.4.522"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12079"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1467-2987(16)31346-0"},{"key":"e_1_2_12_20_2","first-page":"58","article-title":"Effects of two benzodiazepines and a benzodiazepine antagonist on neuromuscular blockade in the anaesthetized cat","volume":"286","author":"Driessen JJ","year":"1987","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.2007.00888.x"},{"key":"e_1_2_12_22_2","first-page":"249","article-title":"Influence of hypnotics on cisatracurium\u2010induced neuromuscular block","volume":"201","author":"Braga\u2010Ade FA","journal-title":"Use of acceleromyograhpy. 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