{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T08:55:18Z","timestamp":1783587318731,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Liver disease is a common cause of morbidity and mortality in dogs. Currently, it is challenging to prognosticate in these cases. The aim of this study was to evaluate the utility of the haematological variables in dogs with chronic hepatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Dogs with chronic hepatitis confirmed on histopathology had presenting haematological values retrospectively obtained and evaluated against survival time. Eighty\u2010two dogs met the inclusion criteria and their data analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Neutrophilic patients, with a count greater than 12\u00d710\n                      <jats:sup>9<\/jats:sup>\n                      \/l, controlled for sex and age, had a shorter survival time (P\u22640.01). In dogs, neutrophilia at presentation predicted a poor outcome, whereas the other haematological parameters were not prognostically informative. When the dogs were split into even quarters on the basis of their neutrophil count, those within the higher quartiles had poorer survival times. Neutrophilia was associated with a poorer survival time in comparison to those patients with a lower count.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The relationship between neutrophils, inflammation and clinical outcome is deserving of future study in dogs with chronic hepatitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/vr.105533","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T17:25:27Z","timestamp":1579800327000},"page":"234-234","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Neutrophilia is associated with a poorer clinical outcome in dogs with chronic hepatitis"],"prefix":"10.1002","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6933-723X","authenticated-orcid":false,"given":"Craig R","family":"Breheny","sequence":"first","affiliation":[{"name":"Hospital for Small Animals University of Edinburgh Royal Dick School of Veterinary Studies Easter Bush UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Handel","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Banner","sequence":"additional","affiliation":[{"name":"Gordons Vets Musselburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elspeth M","family":"Milne","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Unit University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda R","family":"Morrison","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Unit University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sionagh H","family":"Smith","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Unit University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Kilpatrick","sequence":"additional","affiliation":[{"name":"Hospital for Small Animals University of Edinburgh Royal Dick School of Veterinary Studies Easter Bush UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4297-8870","authenticated-orcid":false,"given":"Adam","family":"Gow","sequence":"additional","affiliation":[{"name":"Hospital for Small Animals University of Edinburgh Royal Dick School of Veterinary Studies Easter Bush UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3467-7007","authenticated-orcid":false,"given":"Richard J","family":"Mellanby","sequence":"additional","affiliation":[{"name":"Hospital for Small Animals University of Edinburgh Royal Dick School of Veterinary Studies Easter Bush UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,23]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2010.00996.x"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2016.11.012"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.38-6-628"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15467"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2016.11.008"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0230.x"},{"key":"e_1_2_11_8_2","first-page":"E1","article-title":"Hepatic encephalopathy: etiology, pathogenesis, and clinical signs","volume":"35","author":"Salgado M","year":"2013","journal-title":"Compend Contin Educ Vet"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.247.2.176"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1040638713520602"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1995.tb02801.x"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146560"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15064"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.101306"},{"key":"e_1_2_11_15_2","first-page":"4","article-title":"Neutrophil lymphocyte ratio: APrognostic marker in acute ST elevation myocardial infarction","volume":"27","author":"Gul U","year":"2017","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22189"},{"key":"e_1_2_11_17_2","article-title":"Preoperative monocyte\u2010lymphocyte and neutrophil\u2010lymphocyte but not platelet\u2010lymphocyte ratios are predictive of clinical outcomes in resected patients with non\u2010metastatic Siewert type II\/III adenocarcinoma of esophagogastric junction: a prospective cohort study (the AMONP corhort)","volume":"8","author":"Zhang J\u2010W","year":"2017","journal-title":"Oncotarget"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2015.10.002"},{"key":"e_1_2_11_19_2","article-title":"Preoperative neutrophil\u2010to\u2010lymphocyte ratio is a predictor of survival of epithelial ovarian cancer: a systematic review and meta\u2010analysis of observational studies","volume":"8","author":"Yang Z","year":"2017","journal-title":"Oncotarget"},{"key":"e_1_2_11_20_2","article-title":"Prognostic significance of neutrophil\u2010to\u2010lymphocyte ratio in patients with malignant pleural mesothelioma: a meta\u2010analysis","volume":"8","author":"Chen N","year":"2017","journal-title":"Oncotarget"},{"key":"e_1_2_11_21_2","first-page":"313","article-title":"[Change of Blood Neutrophil\u2010to\u2010Lymphocyte Ratio Predicts Survival in Patients with Metastatic Colorectal Cancer]","volume":"44","author":"Muneoka K","year":"2017","journal-title":"Gan To Kagaku Ryoho"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2017.01.008"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12274"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12435"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199106000-00001"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.4.1226"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-40-6-1038"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1053\/rvsc.1998.0243"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00069"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.24.8.746"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1159\/000104806"},{"key":"e_1_2_11_32_2","first-page":"408","article-title":"Diagnostic value of IL\u20106, CRP, WBC, and absolute neutrophil count to predict serious bacterial infection in febrile infants","volume":"53","author":"Zarkesh M","year":"2015","journal-title":"Acta Med Iran"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800640512"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.10.023"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-005-1761-5"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-012-0942-x"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23367"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-018-9725-1"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200644"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22474"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21737"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.37.11"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep42253"}],"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/vr.105533","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1136\/vr.105533","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1136%2Fvr.105533","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/vr.105533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:04:26Z","timestamp":1761563066000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1136\/vr.105533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,23]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1136\/vr.105533"],"URL":"https:\/\/doi.org\/10.1136\/vr.105533","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,23]]}}}