{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T05:50:27Z","timestamp":1791697827538,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary hyperparathyroidism (PHPT) is an uncommon condition in dogs, for which there is a documented genetic predisposition in Keeshonden and sporadic cases in other breeds. Secondary literature reports a 10 per cent prevalence for recurrence in patients successfully treated by surgical parathyroidectomy, however there is no published primary literature available on which to base this assertion. This study sought to document prevalence of recurrence within Keeshonden and non\u2010Keeshonden breeds. The authors hypothesised that Keeshonden would have a higher rate of recurrence due to the genetic predisposition for the disease, as compared with sporadic cases in other breeds, and that Keeshonden might have an earlier age of detection of disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review of medical records was undertaken to assess the prevalence of recurrence, the length of time after diagnosis that the recurrence occurred, and the age of initial diagnosis in both Keeshonden and non\u2010Keeshonden breeds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study found that Keeshonden were significantly more likely to develop recurrence (6\/12, 50 per cent) than non\u2010Keeshonden dogs (1\/15, 7 per cent) (P=0.024), and were significantly younger (median 108 v 126\u00a0months, P=0.043) at initial disease detection. Recurrence in Keeshonden occurred at median 35\u00a0months after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This suggests all dogs treated by curative parathyroidectomy for PHPT should be monitored lifelong for recurrence of disease, and that this is particularly pertinent in the Keeshond population. Earlier screening of younger, apparently healthy Keeshonden may also be advisable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/vr.105563","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T17:15:37Z","timestamp":1595265337000},"update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence of canine primary hyperparathyroidism recurrence in Keeshond and non\u2010Keeshond dogs after curative parathyroidectomy"],"prefix":"10.1002","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0414-7312","authenticated-orcid":false,"given":"Dan","family":"Thompson","sequence":"first","affiliation":[{"name":"Davies Veterinary Specialists Hitchin Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Skelly","sequence":"additional","affiliation":[{"name":"Veterinary Medicine University of Cambridge Cambridge CB3 0ES United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"e_1_2_13_2_2","first-page":"1715","volume-title":"Textbook of veterinary internal medicine","author":"Skelly BJ","year":"2017"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113555"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199507203330307"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4557-4456-5.00015-8"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u2010950X.2008.00457.x"},{"key":"e_1_2_13_7_2","first-page":"382","article-title":"Canine primary hyperparathyroidism","volume":"31","author":"Schaefer C","year":"2009","journal-title":"Compend Contin Educ Vet"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018\u201002789"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012\u20102303"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12022\u2010013\u20109294\u20103"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31815c3ffd"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE\u201009\u20100789"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300253"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2492"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u20101676.2007.tb02948.x"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195\u20105616(01)50012\u20101"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2006.10.018"},{"key":"e_1_2_13_18_2","unstructured":"Raleigh: American kennel Club canine health Foundation Inc; c2018. 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