{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:53:36Z","timestamp":1778630016312,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T00:00:00Z","timestamp":1598659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The administration of cytosine arabinoside (CA) by continuous rate infusion (CRI) at the time of diagnosis has been shown to improve the 3\u2010month survival of dogs diagnosed with meningoencephalomyelitis of unknown origin (MUO), compared to subcutaneous administration. The benefit of administering subsequent sequential CA subcutaneous injections is unknown. This study compares the outcomes of a CA CRI protocol with (CRI+subcutaneous group) or without (CRI group) follow\u2010up CA subcutaneous injections; both groups received adjunctive prednisolone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010two dogs diagnosed with MUO were recruited (CRI group) and compared with 41 historical control dogs (CRI+subcutaneous group) in a prospective, controlled clinical trial with 36\u00a0months of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Success rates were respectively 64.3 per cent and 65 per cent in the CRI and the CRI+subcutaneous groups at 40 weeks following diagnosis, and 32.5 per cent and 35.9 per cent at 36\u00a0months following diagnosis. The median time to relapse was 299 and 285\u00a0days for the CRI and the CRI+subcutaneous groups, respectively. No statistically significant difference was found (P\u22650.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>No clear benefit was identified in the administration of subsequent sequential CA subcutaneous injections after the first administration of CA by CRI for the treatment of dogs diagnosed with MUO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/vr.106019","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T17:20:31Z","timestamp":1598721631000},"update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Cytosine arabinoside constant rate infusion without subsequent subcutaneous injections for the treatment of dogs with meningoencephalomyelitis of unknown origin"],"prefix":"10.1002","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5208-2605","authenticated-orcid":false,"given":"Kimberley","family":"Stee","sequence":"first","affiliation":[{"name":"Neurology Dovecote Veterinary Hospital Castle Donington Derbyshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6742-3911","authenticated-orcid":false,"given":"Bart J G","family":"Broeckx","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Genetics Ghent University Merelbeke Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Targett","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery University of Nottingham Loughborough UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9452-7262","authenticated-orcid":false,"given":"Sergio A","family":"Gomes","sequence":"additional","affiliation":[{"name":"Neurology Dovecote Veterinary Hospital Castle Donington Derbyshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4993-589X","authenticated-orcid":false,"given":"Mark","family":"Lowrie","sequence":"additional","affiliation":[{"name":"Neurology Dovecote Veterinary Hospital Castle Donington Derbyshire 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