{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:03:34Z","timestamp":1791011014787,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1997,8,2]],"date-time":"1997-08-02T00:00:00Z","timestamp":870480000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[1997,8]]},"abstract":"<jats:p>\n                    Three groups of newly\u2010weaned Romney lambs were given either a standard oral dose of albendazole, a controlledrelease capsule containing albendazole, or a standard oral dose of moxidectin. At 10, 20, 30 and 40\u00a0days after treatment, sub\u2010groups of lambs were given 10,000\u00a0infectivestage larvae of either a drug\u2010resistant or a drug\u2010susceptible strain of\n                    <jats:italic>Ostertagia circumcincta<\/jats:italic>\n                    . The recommended oral dose of albendazole removed 32 per cent of the resistant strain and over 99.9 per cent of the susceptible\n                    <jats:italic>O circumcincta<\/jats:italic>\n                    . The recommended oral dose of moxidectin removed 91 per cent of the resistant strain and over 99.9 per cent of the susceptible parasites. None of the lambs treated with controlled\u2010release capsules was challenged at 20 or 30\u00a0days after treatment. Twenty\u2010one days after challenge, samples of faeces were taken to determine the presence of nematode eggs and cultured to establish the proportion of eggs developing to infective\u2010stage larvae (L3). Abomasa were recovered after slaughter and worm burdens determined. In the lambs given controlledrelease capsules only the resistant parasites were able to establish, and there were significantly fewer than in the lambs treated orally with albendazole. The proportion of the eggs from resistant parasites which developed to L3 was not reduced by the presence of the capsules. Oral moxidectin provided no protection against the establishment of the resistant strain and viable L3 were recovered after challenge with resistant parasites 10\u00a0days after treatment; however, the establishment of susceptible\n                    <jats:italic>O circumcincta<\/jats:italic>\n                    was reduced by more than 99 per cent. The establishment of the susceptible parasites in the lambs treated with moxidectin increased with time and was not significantly lower than in the other groups by 30\u00a0days after treatment.\n                  <\/jats:p>","DOI":"10.1136\/vr.141.5.120","type":"journal-article","created":{"date-parts":[[2010,10,4]],"date-time":"2010-10-04T23:02:24Z","timestamp":1286233344000},"page":"120-123","source":"Crossref","is-referenced-by-count":22,"title":["Prophylactic efficacy of persistent anthelmintics against challenge with drug\u2010resistant and susceptible\n                    <i>Ostertagia circumcincta<\/i>"],"prefix":"10.1002","volume":"141","author":[{"given":"I. A.","family":"Sutherland","sequence":"first","affiliation":[{"name":"AgResearch Grasslands, Private Bag 11008 Palmerston North New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Leathwick","sequence":"additional","affiliation":[{"name":"AgResearch Grasslands, Private Bag 11008 Palmerston North New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. E.","family":"Brown","sequence":"additional","affiliation":[{"name":"AgResearch Grasslands, Private Bag 11008 Palmerston North New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Miller","sequence":"additional","affiliation":[{"name":"AgResearch Grasslands, Private Bag 11008 Palmerston North New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1997,8,2]]},"reference":[{"key":"e_1_2_1_10_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf00044a037"},{"key":"e_1_2_1_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)32638-9"},{"key":"e_1_2_1_10_4_1","unstructured":"BAIRDEN K. DUNCAN J. O.&MUDD A. J.(1993)Proceedings of the 14th International Conference of the World Association for the Advancement of Veterinary Parasitology August 8\u201013 Cambridge p131"},{"key":"e_1_2_1_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1993.tb15136.x"},{"key":"e_1_2_1_10_6_1","first-page":"31","volume":"64","author":"ECHEVARRIA F. A. M.","year":"1993","journal-title":"Journal of the South African Veterinary Association"},{"key":"e_1_2_1_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.130.16.351"},{"key":"e_1_2_1_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.137.16.399"},{"key":"e_1_2_1_10_9_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0034-5288(18)32459-7","volume":"31","author":"LE JAMBRE L. F.","year":"1981","journal-title":"Research in Veterinary Science"},{"key":"e_1_2_1_10_10_1","first-page":"167","volume":"65","author":"PETER R. J.","year":"1994","journal-title":"Journal of the South African Veterinary Association"},{"key":"e_1_2_1_10_11_1","unstructured":"ROLFE P. F.&FITZGIBBON C.(1996)Proceedings of the 2nd Pan Pacific Veterinary Conference Christchurch. p183"},{"key":"e_1_2_1_10_12_1","unstructured":"ROLFE P. F. LOUGHLIN K. NICHOLS G. K.&MONTGOMERY J.(1995)Proceedings of the Australian Sheep Veterinary Society. 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