{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T11:09:28Z","timestamp":1761476968488,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[1998,4,18]],"date-time":"1998-04-18T00:00:00Z","timestamp":892857600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"IRPA","award":["51210"],"award-info":[{"award-number":["51210"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[1998,4]]},"abstract":"<jats:p>\n                    A trial was conducted to compare the efficacy of intranasal vaccination in protecting goats against pneumonic pasteurellosis with intramuscular vaccination using an oil adjuvant vaccine, and a combination of the two methods. Forty goats were divided into four equal groups. Group 1 was vaccinated twice intranasally with formalin\u2010killed\n                    <jats:italic>Pasteurella haemolytica<\/jats:italic>\n                    A2, group 2 was vaccinated twice intramuscularly with an oil adjuvant vaccine containing\n                    <jats:italic>P haemolytica<\/jats:italic>\n                    A7, and group 3 was initially vaccinated intranasally with the formalin\u2010killed\n                    <jats:italic>P haemolytica<\/jats:italic>\n                    A2 followed by intramuscular vaccination with the oil adjuvant vaccine. In each group the two vaccinations were carried out four weeks apart. Group 4 was the unvaccinated control group. All goats were challenged intratracheally with 4\u00a0ml of an inoculum containing live\n                    <jats:italic>P haemolytica<\/jats:italic>\n                    A2 at a concentration of 1.3 \u00d7 10\n                    <jats:sup>7<\/jats:sup>\n                    colony forming units\/ml two weeks after the last vaccination and were killed 14\u00a0days after the challenge. Although group 2 showed the highest clinical score following the challenge, deaths were observed only in group 3. Three goats in group 1 had pneumonic lung lesions, compared with six goats in group 2 and all the goats in groups 3 and 4. The lung lesions in group 1 were significantly (P&lt;0.05) less severe than in groups 3 and 4. Similarly, the lesions in group 2 were markedly less severe than in groups 3 and 4, although the differences were not significant. The difference between the extent of the lung lesions in the goats in groups 1 and 2 was not significant. Antibody against\n                    <jats:italic>P haemolytica<\/jats:italic>\n                    A2\u00a0in group 1 reached peak levels and was significantly (P&lt;0.01) higher than in the control group one week after the second vaccination, before declining.\n                  <\/jats:p>","DOI":"10.1136\/vr.142.16.428","type":"journal-article","created":{"date-parts":[[2010,10,4]],"date-time":"2010-10-04T23:03:59Z","timestamp":1286233439000},"page":"428-431","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy of intranasal administration of formalin\u2010killed\n                    <i>Pasteurella haemolytica<\/i>\n                    A2 against intratracheal challenge in goats"],"prefix":"10.1002","volume":"142","author":[{"given":"A. W. M.","family":"Effendy","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine and Animal Science Universiti Putra Malaysia 43400 Serdang Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Zamri\u2010Saad","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine and Animal Science Universiti Putra Malaysia 43400 Serdang Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Puspa","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine and Animal Science Universiti Putra Malaysia 43400 Serdang Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Rosiah","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine and Animal Science Universiti Putra Malaysia 43400 Serdang Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1998,4,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.1990.35609"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1935(91)90086-3"},{"key":"e_1_2_6_4_1","first-page":"179","volume":"59","author":"CONLON J. 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L.","year":"1983","journal-title":"Research in Veterinary Science"},{"key":"e_1_2_6_12_1","unstructured":"JAMALUDIN R.(1993)Pasteurellosis in Production Animals. EdsB. E.Patten T. L.Spencer R. B.Johnson D.Hoffman L.Lehane. aciar Proceedings No 43. p238"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1935(91)90008-B"},{"key":"e_1_2_6_14_1","unstructured":"MOSIER D.(1993)Pasteurellosis in Production Animals. EdsB. E.Patten T. L.Spencer R. B.Johnson D.Hoffman L.Lehane. aciar Proceedings No 43. p121"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.2460\/ajvr.1991.52.08.1214","volume":"52","author":"PURDY C. W.","year":"1991","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.2460\/ajvr.1990.51.10.1629","volume":"51","author":"PURDY C. 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