{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:09:18Z","timestamp":1791058158821,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[1998,10,10]],"date-time":"1998-10-10T00:00:00Z","timestamp":907977600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:p>\n                    Seven beagles were inoculated experimentally with a Swedish canine\n                    <jats:italic>Ehrlichia<\/jats:italic>\n                    species isolate to study its pathogenicity. With respect to the 16S rRNA gene sequence, the isolate was identical to the human granulocytic ehrlichiosis (HGE) agent and closely related to both\n                    <jats:italic>Ehrlichia equi<\/jats:italic>\n                    and\n                    <jats:italic>E phagocytophila<\/jats:italic>\n                    . After an incubation period of four to 11\u00a0days, the most prominent clinical signs were high fever for two to five days and depression. AU the dogs developed profound thrombocytopenia, moderate leukopenia and a strong serological antibody response. Ehrlichial inclusions were detected in blood neutrophils from four to 14\u00a0days after inoculation for four to eight days. Ehrlichial DNA could be detected by polymerase chain reaction during the parasitaemic stage and a few days before and after microscopic inclusions were visible. Postmortem, the dogs showed reactive splenic hyperplasia and non\u2010specific mononuclear reactive hepatitis.\n                  <\/jats:p>","DOI":"10.1136\/vr.143.15.412","type":"journal-article","created":{"date-parts":[[2010,10,4]],"date-time":"2010-10-04T23:03:59Z","timestamp":1286233439000},"page":"412-417","source":"Crossref","is-referenced-by-count":56,"title":["Early manifestations of granulocytic ehrlichiosis in dogs inoculated experimentally with a Swedish Ehrlichia species isolate"],"prefix":"10.1002","volume":"143","author":[{"given":"A.","family":"Egenvall","sequence":"first","affiliation":[{"name":"Department of Small Animal Clincial Sciences Swedish University of Agricultural Sciences Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bj\u00f6ersdorff","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Kalmar County Hospital Kalmar Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lillieh\u00f6\u00f6k","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry Swedish University of Agricultural Sciences Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Olsson Engvall","sequence":"additional","affiliation":[{"name":"Department of Bacteriology National Veterinary Institute Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Karlstam","sequence":"additional","affiliation":[{"name":"Department of Pathology Swedish University of Agricultural Sciences Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Artursson","sequence":"additional","affiliation":[{"name":"Department of Bacteriology National Veterinary Institute Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5.","family":"Hedhammar","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clincial Sciences Swedish University of Agricultural Sciences Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gunnarsson","sequence":"additional","affiliation":[{"name":"Department of Bacteriology National Veterinary Institute Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1998,10,10]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"331","volume":"46","author":"ARTURSSON K.","year":"1994","journal-title":"Svensk Veterin\u00e4r Tidning"},{"key":"e_1_2_6_3_1","first-page":"549","volume":"41","author":"BELLSTR\u00d6M L.","year":"1989","journal-title":"Svensk Veterin\u00e4r Tidning"},{"key":"e_1_2_6_4_1","volume-title":"Proceedings of the 4th International Symposium on Rickettsiae and Rickettsial diseases, Piestani Spa","author":"BJ\u00d6ERSDORFF A.","year":"1990"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/130.4.357"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.2460\/ajvr.1971.32.05.749","volume":"32","author":"BURGHEN G. 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