{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T14:48:30Z","timestamp":1770216510572,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[1998,8,29]],"date-time":"1998-08-29T00:00:00Z","timestamp":904348800000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Federal Veterinary Office and the National Science Foundation","award":["31-45609.95"],"award-info":[{"award-number":["31-45609.95"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[1998,8]]},"abstract":"<jats:p>Sporadically occurring non\u2010suppurative encephalitis appears to be a frequent condition of Swiss cattle. Fifty\u2010one such cases diagnosed over a period of 10 years were examined retrospectively to investigate whether they constituted one or more distinct diseases, and to search for aetiological agents. Three cases were characterised by periventricular granulomatous encephalitis, and most probably represented a different disease, but the remaining 48 cases had disseminated non\u2010suppurative encephalitis with widespread neuronal changes. Neuronal degeneration was very marked in the hippocampus of 10 cases and in the cerebellar Purkinje cells of 11. It was thought that the latter cases represented morphological variations of the same disease rather than a different disease because of their overlapping morphological features. The 48 cases had the following features in common: the disease had primarily neurological signs affecting mostly adult cattle, it was a sporadic condition, and there was a clear tendency for it to have a subacute to chronic course. Polymerase chain reaction (PCR) amplification for chlamydial DNA was negative except in one of 32 specimens, and immunohistochemistry did not demonstrate the presence of chlamydial antigens either in the one PCR\u2010positive case or in the other cases examined. Immunohistochemistry for rabies virus, Borna disease virus, and central European tickborne encephalitis virus was negative. In four cases, immunolabelled cells were found in the lesions with antibodies against paramyxovirus antigens.<\/jats:p>","DOI":"10.1136\/vr.143.9.244","type":"journal-article","created":{"date-parts":[[2010,10,4]],"date-time":"2010-10-04T23:03:59Z","timestamp":1286233439000},"page":"244-249","source":"Crossref","is-referenced-by-count":33,"title":["Neuropathological and aetiological studies of sporadic non\u2010suppurative meningoencephalomyelitis of cattle"],"prefix":"10.1002","volume":"143","author":[{"given":"D.","family":"Theil","sequence":"first","affiliation":[{"name":"Institute of Animal Neurology BSE Reference Centre University of Berne PO Box 2735 CH\u20103012 Beme Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Fatzer","sequence":"additional","affiliation":[{"name":"Institute of Animal Neurology BSE Reference Centre University of Berne PO Box 2735 CH\u20103012 Beme Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Schiller","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology University of Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Caplazi","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology University of Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zurbriggen","sequence":"additional","affiliation":[{"name":"Institute of Animal Neurology BSE Reference Centre University of Berne PO Box 2735 CH\u20103012 Beme Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Vandevelde","sequence":"additional","affiliation":[{"name":"Institute of Animal Neurology BSE Reference Centre University of Berne PO Box 2735 CH\u20103012 Beme Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1998,8,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1099\/0022-1317-43-3-623","volume":"43","author":"BACHMANN P. 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