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Ultrastructurally, the pigment in the neurons occurred predominantly as electron\u2010dense membranous whorls and stacks. There were a few vacuolated macrophages in the meninges. Hepatocytes were highly vacuolated and electron microscopy suggested that they were empty membrane\u2010bound vesicles. The disease was diagnosed as mucopolysaccharidosis IIIA because of its similarity to other biochemically confirmed cases in the same breed and in a New Zealand huntaway dog. Additional lesions included calcium oxalate uroliths, severe secondary calcification of tissues including the brain and storage deposits in some neurons, and lesions which may have been associated with high levels of the substrate, heparan sulphate.<\/jats:p>","DOI":"10.1136\/vr.148.18.564","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T02:18:07Z","timestamp":1286245087000},"page":"564-567","source":"Crossref","is-referenced-by-count":8,"title":["Histological diagnosis of mucopolysaccharidosis IIIA in a wire\u2010haired dachshund"],"prefix":"10.1002","volume":"148","author":[{"given":"R. D.","family":"Jolly","sequence":"first","affiliation":[{"name":"Institute of Veterinary, Animal and Biomedical Sciences Private bag 11\u2010222 Palmerston North New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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