{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:49:38Z","timestamp":1791118178933,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,1,27]],"date-time":"2001-01-27T00:00:00Z","timestamp":980553600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hoechst Roussel Vet"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>\n                    The efficacy of halofuginone lactate in the prevention of cryptosporidiosis in suckling calves was evaluated in a multicentre, control versus placebo, randomised, double.blind clinical trial. Seventy\u2010eight six\u2010 to 48\u2010 hour\u2010old calves were treated daily with 120 \u03bcg\/kg bodyweight of halofuginone lactate administered orally for seven consecutive days, while 80\u00a0calves received a placebo. Faecal samples were collected on the first day of dosing and four, seven, 14 and 21\u00a0days later, and\n                    <jats:italic>Cryptosporidium parvum<\/jats:italic>\n                    oocysts were counted and faecal indices for diarrhoea were determined after a clinical examination. An analysis of variance for repeated measurements showed a highly significant difference in favour of halofuginone lactate for both the oocyst counts (P=0.0002) and the faecal diarrhoea indices (P=0.0001) throughout the trial. The difference was greatest after seven days, when the mean oocyst count of the placebo group was 2.5 times and its mean faecal index was twice the mean of the halofuginone lactate group. One day after the end of the treatment the calves which received halofuginone lactate excreted 44 per cent fewer\n                    <jats:italic>C parvum<\/jats:italic>\n                    oocysts and 44 per cent fewer of them had diarrhoea. The reduction was even greater (65 per cent) when liquid diarrhoea was assessed, with 32.5 per cent of the calves in the placebo group having liquid diarrhoea compared with 11.5 per cent in the halofuginone lactate group. The treatment was well tolerated and easily administered.\n                  <\/jats:p>","DOI":"10.1136\/vr.148.4.108","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T02:18:07Z","timestamp":1286245087000},"page":"108-112","source":"Crossref","is-referenced-by-count":61,"title":["Efficacy of halofuginone lactate in the prevention of cryptosporidiosis in suckling calves"],"prefix":"10.1002","volume":"148","author":[{"given":"D.","family":"Lefay","sequence":"first","affiliation":[{"name":"Soci\u00e9t\u00e9 Protocole Les Algorithmes 91194 Saint Aubin Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Naciri","sequence":"additional","affiliation":[{"name":"Unite de Pathologie Aviaire et de Parasitologie 37380 Nouzilly France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Poirier","sequence":"additional","affiliation":[{"name":"Hoechst Roussel Vet 140 avenue Jean Lolive 93695 Pantin Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Chermette","sequence":"additional","affiliation":[{"name":"Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort UMR Biologie Mol\u00e9culaire et Immunologie Parasitaires et Fongiques INRA\u2010AFSSAENVA 7 avenue du G\u00e9n\u00e9ral de Gaulle 94704 Maisons Alfort Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,1,27]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"485","article-title":"SAC Veterinary Services: Surveillance of neonatal enteritis in cattle","volume":"139","author":"ANON","year":"1996","journal-title":"Veterinary Record"},{"key":"e_1_2_6_3_1","first-page":"321","article-title":"SAC Veterinary Services: report for June 1997","volume":"141","author":"ANON","year":"1997","journal-title":"Veterinary Record"},{"key":"e_1_2_6_4_1","first-page":"83","volume-title":"Cryptosporidiosis of Man and Animals","author":"ANGUS K. 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