{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:42:33Z","timestamp":1763746953666,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,8,11]],"date-time":"2001-08-11T00:00:00Z","timestamp":997488000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:p>\n                    Haemostasis was evaluated in 19 dogs with natural\n                    <jats:italic>Leishmania infection<\/jats:italic>\n                    , six of them with a history of epistaxis, and the results were compared with the results from 24 healthy dogs. In addition, the dogs' blood pressure was measured and biopsies were taken from the nasal mucosa. Buccal mucosa bleeding time was prolonged in the dogs with leishmaniasis (P&lt;0.002) and most significantly in those with epistaxis (P&lt;0.05). None of the Leishmania\u2010infected dogs had thrombocytopenia, low levels of plasma von Willebrand factor antigen, a prolonged prothrombin time or activated partial thromboplastin time, a low plasma fibrinogen concentration or high serum fibrin degradation products. These results rule out defects of secondary haemostasis or disseminated intravascular coagulation as significant causes of epistaxis in non\u2010complicated leishmaniasis. Histopathology of the nasal mucosa of 10 of the affected dogs, three of them with epistaxis, revealed ulcerative and inflammatory lesions in all of them.\n                  <\/jats:p>","DOI":"10.1136\/vr.149.6.176","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T02:18:07Z","timestamp":1286245087000},"page":"176-179","source":"Crossref","is-referenced-by-count":16,"title":["Evaluation of the potential causes of epistaxis in dogs with natural visceral leishmaniasis"],"prefix":"10.1002","volume":"149","author":[{"given":"C.","family":"Juttner","sequence":"first","affiliation":[{"name":"Departamento Patologia Animal II Facultad de Veterinaria UCM (Hospital Clinico Veterinario) Avenida Puerta de Hierro Madrid 28040 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rodriguez Sinchez","sequence":"additional","affiliation":[{"name":"Departamento Patologia Animal II Facultad de Veterinaria UCM (Hospital Clinico Veterinario) Avenida Puerta de Hierro Madrid 28040 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Rollin Landeras","sequence":"additional","affiliation":[{"name":"Departamento Patologia Animal II Facultad de Veterinaria UCM (Hospital Clinico Veterinario) Avenida Puerta de Hierro Madrid 28040 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Fragio Arnold","sequence":"additional","affiliation":[{"name":"Departamento Patologia Animal II Facultad de Veterinaria UCM (Hospital Clinico Veterinario) Avenida Puerta de Hierro Madrid 28040 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Slappendel","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals Veterinary Faculty Utrecht University PO Box 80.154 3508 TD Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,8,11]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1994.11812879"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1996.tb02358.x"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(88)90137-5"},{"key":"e_1_2_2_5_1","first-page":"55","article-title":"von Willebrand factor is not altered in azotemic dogs with prolonged bleeding time","volume":"124","author":"BRASSARD J. 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