{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T22:08:54Z","timestamp":1770070134744,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2001,8,18]],"date-time":"2001-08-18T00:00:00Z","timestamp":998092800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:p>\n                    Acid\u2010base balance and electrolyte concentrations, including ionised calcium, were monitored during intravenous fluid therapy of 1 1 collapsed diarrhoeic suckler calves aged five to 10\u00a0days. Six healthy calves of similar age and type were used to provide control data. All the diarrhoeic calves were severely acidotic (TCO\n                    <jats:sub>2<\/jats:sub>\n                    &lt;12\u00a0mmol\/litre). Isotonic sodium bicarbonate (1.3 per cent) was administered until the metabolic acidosis was half corrected, as indicated by the TCO\n                    <jats:sub>2<\/jats:sub>\n                    increasing to 17 to 24\u00a0mmol\/litre when the infusion was changed to an extracellular volume replacement fluid containing 144\u00a0mmol\/litre Na\n                    <jats:sup>+<\/jats:sup>\n                    , 35\u00a0mmol\/litre HCO\n                    <jats:sup>\u2010<\/jats:sup>\n                    <jats:sub>3<\/jats:sub>\n                    , 4\u00a0mmol\/litre K\n                    <jats:sup>+<\/jats:sup>\n                    and 113\u00a0mmol\/litre Cl\u2010 which was administered until the calf was discharged. Milk feeding was started as soon as the calf had a suck reflex. The treatment was successful in 10\u00a0calves. At admission the diarrhoeic calves were hypocalcaemic compared with the control calves, but their ionised calcium was significantly higher, with significantly less calcium being protein bound. Treatment with isotonic sodium bicarbonate resulted in a significant improvement in acid\u2010base balance, but both total and ionised calcium decreased significantly, the decrease in ionised calcium being proportionately greater owing partly to a significant increase in the protein binding of calcium. The mean total, bound and ionised calcium concentrations were all significantly lower in the treated calves after they had received isotonic sodium bicarbonate than in the control calves. Further treatment with replacement fluid had no significant effect on any of the parameters apart from pCO\n                    <jats:sub>2<\/jats:sub>\n                    which increased significantly. Milk feeding had no significant effect on plasma calcium concentrations. The calves' mean ionised calcium concentration was significantly lower at the end of the treatment than before it, but there was no difference in the mean total and bound calcium concentrations. The calves' mean plasma potassium and magnesium concentrations decreased significantly during the course of the treatment.\n                  <\/jats:p>","DOI":"10.1136\/vr.149.7.203","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T02:18:07Z","timestamp":1286245087000},"page":"203-207","source":"Crossref","is-referenced-by-count":8,"title":["Iatrogenic hypocalcaemia during parenteral fluid therapy of diarrhoeic calves"],"prefix":"10.1002","volume":"149","author":[{"given":"D. H.","family":"Grove\u2010White","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Studies University of Liverpool, Leahurst Neston Wirral CH64 7TE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. R.","family":"Michell","sequence":"additional","affiliation":[{"name":"Mill Barn Mill Lane, Exning Newmarket Suffolk CB8 7JW"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,8,18]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2460\/javma.1987.191.02.235","article-title":"Hypocalcaemia associated with administration of sodium bicarbonate for salicylate intoxication in a cat","volume":"191","author":"ABRAMS K. L.","year":"1987","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_2_3_1","first-page":"424428","article-title":"Biochemical studies of the 'collapse syndrome' in suckled calves","volume":"97","author":"BARBER D. M. L.","year":"1975","journal-title":"Veterinary Record"},{"key":"e_1_2_2_4_1","first-page":"1009","volume-title":"Maxwell and Kleeman's Clinical Disorders of Fluid and Electrolyte Metabolism","author":"BENABE J. 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