{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:41:52Z","timestamp":1780519312617,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2002,4,6]],"date-time":"2002-04-06T00:00:00Z","timestamp":1018051200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:p>\n                    A novel intranasal vaccine against disease caused by\n                    <jats:italic>Bordetella bronchiseptica<\/jats:italic>\n                    in cats was tested in a series of three experiments. In the first experiment a vaccinated group and an unvaccinated control group of kittens were challenged by the aerosol route with virulent\n                    <jats:italic>B bronchiseptica<\/jats:italic>\n                    three weeks after they had been vaccinated. The control kittens developed upper respiratory tract signs typical of feline\n                    <jats:italic>B bronchiseptica<\/jats:italic>\n                    infection, including rhinitis, a serous ocular and nasal discharge, fever, sneezing and coughing. The mean (sd) clinical score for the cats in the unvaccinated control group was 19.5 (5.4) compared with 1.53 (1.9) for the vaccinated group. In the second experiment vaccinated kittens were challenged with virulent\n                    <jats:italic>B bronchiseptica<\/jats:italic>\n                    72 hours after they were vaccinated. Their mean clinical score was 2.76 (2.62) compared with 13.4 (3.33) for the control group. In the final experiment, vaccinated and unvaccinated control cats were challenged after six or 12\u00a0months. After six months the mean clinical scores were 13.9 (4.7) for the control group, compared with 1.33 (1.56) for the vaccinated group, and after 12\u00a0months the scores were 9.92 (5.79) for the control group compared with 0.92 (0.89) for the vaccinated group.\n                  <\/jats:p>","DOI":"10.1136\/vr.150.14.439","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T02:27:44Z","timestamp":1286245664000},"page":"439-442","source":"Crossref","is-referenced-by-count":14,"title":["Studies of the efficacy of a novel intranasal vaccine against feline bordetellosis"],"prefix":"10.1002","volume":"150","author":[{"given":"J.","family":"Williams","sequence":"first","affiliation":[{"name":"AAS Intervet Inc 405 State Street, PO Box 318 Millsboro DE 19966 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Laris","sequence":"additional","affiliation":[{"name":"AAS Intervet Inc 405 State Street, PO Box 318 Millsboro DE 19966 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. W.","family":"Gray","sequence":"additional","affiliation":[{"name":"Intervet International BV Wim de Korvestraat 35, PO Box 31 5830 AA Boxmeer The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A. C.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Intervet International BV Wim de Korvestraat 35, PO Box 31 5830 AA Boxmeer The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,4,6]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Virus Infections of Vertebrates","author":"APPEL M.","year":"1987"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1997.9694809"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.144.21.575"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/jfms.2000.0084"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(95)00128-X"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.146.2.46"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2460\/ajvr.1983.44.02.207","article-title":"Comparison of an infective avirulent and canine virulent Bordetella bronchiseptica","volume":"44","author":"GOODNOW R. A.","year":"1983","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.133.11.260"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/vr.135.21.506","article-title":"Seroprevalence and isolation rate of Bordetella bronchiseptica in cats in the UK","volume":"134","author":"MCARDLE H. C.","year":"1994","journal-title":"Veterinary Record"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(88)90059-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.21825\/vdt.89907","article-title":"Prevalence of Bordetella bronchiseptica infections in cats from different environments","volume":"70","author":"PASMANS F.","year":"2001","journal-title":"Vlaams Diergeneeskundig Tijdschrift"},{"key":"e_1_2_6_13_1","first-page":"153","volume-title":"Feline Infectious Disease","author":"PEDERSEN N.","year":"1988"},{"key":"e_1_2_6_14_1","unstructured":"PENNISI M. G. FERA M. T. MASUCCI M. DE MAJO M.&CARBONE M.(1999)Isolation ofBordetella bronchisepticain cats: clinical and epidemiological evaluation.Proceedings of the IAIEV. Palermo Italy. 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