{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:38:51Z","timestamp":1791823131245,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2002,5,18]],"date-time":"2002-05-18T00:00:00Z","timestamp":1021680000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>Pathological studies were conducted on 91\u00a0Japanese Black cattle with a hereditary disease which induced growth retardation, long hooves and renal failure. In calves one to two months old, no gross abnormalities were observed in the kidneys, but microscopical examinations revealed immature epithelia which were arranged irregularly and not attached to the basement membranes in some proximal tubules. In animals three to 36\u00a0months old, the kidneys had shrunk perceptibly and had grey\u2010white radial streaks; microscopically they showed severe interstitial fibrosis with round\u2010cell infiltration in the outer zone of the medulla and cortex, and reductions in the numbers of glomeruli and tubules. In the fibrotic areas there were immature epithelia with an irregular arrangement, and the basement membrane of the tubules was thickened. It was concluded that renal tubular dysplasia was the primary lesion of the disease, and that interstitial fibrosis and reductions in the numbers of nephrons were secondary lesions.<\/jats:p>","DOI":"10.1136\/vr.150.20.628","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T02:27:44Z","timestamp":1286245664000},"page":"628-632","source":"Crossref","is-referenced-by-count":24,"title":["Pathological changes of renal tubular dysplasia in Japanese Black cattle"],"prefix":"10.1002","volume":"150","author":[{"given":"Y.","family":"Sasaki","sequence":"first","affiliation":[{"name":"Laboratory of Internal Medicine Gifu University 1\u20101 Yanagido Gifu 501\u20101193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Laboratory of Internal Medicine Gifu University 1\u20101 Yanagido Gifu 501\u20101193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kitoh","sequence":"additional","affiliation":[{"name":"Laboratory of Internal Medicine Gifu University 1\u20101 Yanagido Gifu 501\u20101193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Okura","sequence":"additional","affiliation":[{"name":"Laboratory of Internal Medicine Gifu University 1\u20101 Yanagido Gifu 501\u20101193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Laboratory of Internal Medicine Gifu University 1\u20101 Yanagido Gifu 501\u20101193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mizukoshi","sequence":"additional","affiliation":[{"name":"Laboratory of Internal Medicine Gifu University 1\u20101 Yanagido Gifu 501\u20101193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Ohba","sequence":"additional","affiliation":[{"name":"Laboratory of Internal Medicine Gifu University 1\u20101 Yanagido Gifu 501\u20101193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Masegi","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology Division of Veterinary Medicine Faculty of Agriculture Gifu University 1\u20101 Yanagido Gifu 501\u20101193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,5,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.50"},{"key":"e_1_2_5_3_1","first-page":"564","article-title":"Nephronophitisis: a primary tubular basement membrane defect","volume":"55","author":"COHEN A. H.","year":"1986","journal-title":"Laboratory Investigation"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0070-2153(08)60458-5","article-title":"The development of the kidney","volume":"39","author":"DAVIS J.","year":"1998","journal-title":"Current Topics in Developmental Biology"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1997.00235.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00180751"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1152\/physrev.1999.79.4.1157","article-title":"Embryonic epithelia: induction, nephrogenesis, and cell differentiation","volume":"79","author":"HOSTER M. F.","year":"1999","journal-title":"Physiological Reviews"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001090050222"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(97)80048-5"},{"key":"e_1_2_5_10_1","first-page":"457","volume-title":"Pathology of Domestic Animals","author":"MAXIE M. J.","year":"1985"},{"key":"e_1_2_5_11_1","first-page":"117","article-title":"Mechanism of interstitial fibrosis and its impacts for progressive kidney disease","volume":"184","author":"MITARI T.","year":"1998","journal-title":"Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003350010058"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2000.6298"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.149.4.115"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.149.4.115"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588702400209"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5424.103"},{"key":"e_1_2_5_18_1","first-page":"113","article-title":"Mechanism of acute interstitial injury in the kidney","volume":"184","author":"YOSHIOKA K.","year":"1998","journal-title":"Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.133.3.695"}],"container-title":["Veterinary Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1136%2Fvr.150.20.628","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/vr.150.20.628","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:47:55Z","timestamp":1761630475000},"score":1,"resource":{"primary":{"URL":"https:\/\/bvajournals.onlinelibrary.wiley.com\/doi\/10.1136\/vr.150.20.628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":18,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["10.1136\/vr.150.20.628"],"URL":"https:\/\/doi.org\/10.1136\/vr.150.20.628","archive":["Portico"],"relation":{},"ISSN":["0042-4900","2042-7670"],"issn-type":[{"value":"0042-4900","type":"print"},{"value":"2042-7670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5]]}}}