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Polyuria and polydipsia completely resolved in 70 per cent of the dogs that had these problems, and skin changes resolved in 62 per cent of the dogs that had skin abnormalities. There was a significant reduction (P&amp;#60;0.001\u00a0in each case) in both the mean basal and post\u2010adrenocorticotrophic hormone (ACTH) cortisol concentrations after a mean of 12.3\u00a0days of treatment. The post\u2010ACTH cortisol concentration decreased to less than 250\u00a0nmol\/litre in 81 per cent of the dogs within one month of the start of treatment and in another 15 per cent at some later time. The median survival time of the 26 dogs which died was 549 days, and 51 of the dogs were alive at the completion of the study. One was lost to follow up after 241\u00a0days treatment.<\/jats:p>","DOI":"10.1136\/vr.150.26.799","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T02:27:44Z","timestamp":1286245664000},"page":"799-804","source":"Crossref","is-referenced-by-count":117,"title":["Trilostane treatment of 78 dogs with pituitary\u2010dependent hyperadrenocorticism"],"prefix":"10.1002","volume":"150","author":[{"given":"R.","family":"Neiger","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences Royal Veterinary College Hawkshead Lane Hatfield AL9 7TA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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