{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T16:42:10Z","timestamp":1772469730710,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,2,2]],"date-time":"2002-02-02T00:00:00Z","timestamp":1012608000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Canadian Food Inspection Agency's Matching Investment Initiative programme"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:p>One kidney was taken from each of 100 pigs at slaughter; 50 had gross lesions of multifocal interstitial nephritis and 50 had no gross lesions. Forty\u2010nine of the affected kidneys had lesions that were characterised by the presence of either a few randomly distributed or numerous widely disseminated pale foci, 1 to 3\u00a0mm in diameter, on the cortical surface (white\u2010dotted kidneys). Microscopically, these focal inflammatory lesions often had a distinct lymphofollicular pattern (follicular nephritis). Lesions of chronic vasculitis were observed in 21 of the affected kidneys. Histologically, the control kidneys had only small and sparse inflammatory foci. Standard bacterial cultures of kidneys of both groups were not significant, and cultures for the isolation of leptospires were all negative. Virological examination of the kidney homogenates by PCR did not reveal any porcine reproductive and respiratory syndrome virus and only a few cases were positive for the porcine circovirus type 1. However, porcine parvovirus (PPV) and porcine circovirus type 2 (PCV\u20102) were detected in many kidneys of both groups but in a significantly higher proportion of the kidneys with interstitial nephritis. There was a significant association between the lesions and the presence of PPV and PCV\u20102 with odds ratios of 7.5 (P&lt;0.0001) and 3.4 (P=0.0074), respectively, and the odds ratio increased to 22.7 (P&lt;0.0001) when both viruses were identified in the same kidney. However, a subsample of kidneys taken from both groups were negative by immunohistochemistry for the presence of PPV and PCV.2 antigens.<\/jats:p>","DOI":"10.1136\/vr.150.5.139","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T02:27:44Z","timestamp":1286245664000},"page":"139-143","source":"Crossref","is-referenced-by-count":27,"title":["Infectious agents identified in pigs with multifocal interstitial nephritis at slaughter"],"prefix":"10.1002","volume":"150","author":[{"given":"R.","family":"Drolet","sequence":"first","affiliation":[{"name":"D\u00e9partement de pathologie et de microbiologie Universit\u00e9 de Montr\u00e9al St\u2010Hyacinthe PQ Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ribotta","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pathologie et de microbiologie Universit\u00e9 de Montr\u00e9al St\u2010Hyacinthe PQ Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Higgins","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pathologie et de microbiologie Universit\u00e9 de Montr\u00e9al St\u2010Hyacinthe PQ Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"D'Allaire","sequence":"additional","affiliation":[{"name":"D\u00e9partement de sciences cliniques, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire Universit\u00e9 de Montr\u00e9al St\u2010Hyacinthe PQ Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Larochelle","sequence":"additional","affiliation":[{"name":"Laboratoire d'hygi\u00e8ne v\u00e9t\u00e9rinaire et alimentaire Agence canadienne d'inspection des aliments St\u2010Hyacinthe PQ Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Magar","sequence":"additional","affiliation":[{"name":"Laboratoire d'hygi\u00e8ne v\u00e9t\u00e9rinaire et alimentaire Agence canadienne d'inspection des aliments St\u2010Hyacinthe PQ Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,2,2]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063870001200102"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1976.tb09511.x"},{"key":"e_1_2_2_4_1","first-page":"290","article-title":"The prevalence of leptospirosis and its association with multifocal interstitial nephritis in swine at slaughter","volume":"53","author":"BAKER T. 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