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The concentration of \u03b1\u2010tocopherol was measured by high performance liquid chromatography in plasma samples obtained from the affected dogs and from 28 ophthalmoscopically normal, healthy control dogs. The mean (sd) plasma \u03b1\u2010tocopherol concentration in the normal dogs was 20.2 (7.1) \u03bcg\/mI, compared with 1.14 (0.67) \u03bcg\/mI in the 11 affected cocker spaniels. The difference between the two groups remained highly significant when the \u03b1\u2010tocopherol concentrations were expressed relative to the concentrations of the plasma lipids cholesterol and triglycerides. Low plasma concentrations of \u03b1\u2010tocopherol were observed in the four affeded dogs of other breeds, but the finding was not so consistent. The plasma lipid concentrations were normal in the affecded dogs. The deficiency of \u03b1\u2010tocopherol in the affeded dogs appeared to be primary, because there was no clinical, biochemical or pathological evidence of underlying disease, or any indication of a dietary deficiency which might have contributed to the low concentrations of \u03b1\u2010tocopherol.<\/jats:p>","DOI":"10.1136\/vr.151.22.663","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T02:27:44Z","timestamp":1286245664000},"page":"663-667","source":"Crossref","is-referenced-by-count":17,"title":["Vitamin E deficiency in dogs with retinal pigment epithelial dystrophy"],"prefix":"10.1002","volume":"151","author":[{"given":"G. 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