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The attacks were typically elicited by stimulation, such as feeding, and a case of sporadic narcolepsy\u2010cataplexy was therefore suspected. Treatment orally three times a day with 1\u00a0mg\/kg imipramine, was effective in reducing the attacks. The concentration of hypocretin\u20101\/orexin A in the dog's cerebrospinal fluid was less than 80 pg\/ml (22.5 pmol\/litre), compared with normal canine levels of 250 to 350 pg\/ml (70.0 to 98.3 pmol\/litre), supporting a diagnosis of hypocretin\u2010deficient narcolepsy.<\/jats:p>","DOI":"10.1136\/vr.152.25.776","type":"journal-article","created":{"date-parts":[[2010,10,8]],"date-time":"2010-10-08T13:44:05Z","timestamp":1286545445000},"page":"776-779","source":"Crossref","is-referenced-by-count":7,"title":["Narcolepsy in a hypocretin\/orexin\u2010deficient chihuahua"],"prefix":"10.1002","volume":"152","author":[{"given":"M.","family":"Tonokura","sequence":"first","affiliation":[{"name":"Fujita Animal Hospital Ageo Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Fujita","sequence":"additional","affiliation":[{"name":"Fujita Animal Hospital Ageo Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Morozumi","sequence":"additional","affiliation":[{"name":"Fujita Animal Hospital Ageo Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Center for Narcolepsy Stanford University Department of Psychiatry and Behavioral Sciences Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kanbayashi","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Akita University Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Nishino","sequence":"additional","affiliation":[{"name":"Center for Narcolepsy Stanford University Department of Psychiatry and Behavioral Sciences Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,6,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(82)90038-3"},{"key":"e_1_2_5_3_1","first-page":"387","volume-title":"The Pharmacological Basis of Therapeutics","author":"BALDESSARINI R. 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