{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T09:02:23Z","timestamp":1761642143754,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,2,7]],"date-time":"2003-02-07T00:00:00Z","timestamp":1044576000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Record"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:p>Freemartins are XX\/XY chimaeras that develop as a result of the fusion of the placental circulation of at least one male and one female fetus. Of 19 freemartin ewes, 13 had testis\u2010like structures, seven of them in an abdominal position and six in an inguinal position. Histologically, their gonads had structures resembling seminiferous tubules and interstitial cells, and grossly, most had structures derived from the mesonephric ducts (vasa deferentia, epididymides and vesicular glands). The other six freemartin ewes had small, undifferentiated gonads that lacked either follicles or seminiferous tubule\u2010like structures. They also lacked any structures derived from the mesonephric ducts. No derivatives of the paramesonephric ducts were detectable in any of the freemartin ewes. The gonads of the male\u2010type freemartins stained immunocytochemically for 3\u03b2\u2010hydroxysteroid dehydrogenase (3\u03b2\u2010HSD) and histochemically for alkaline phosphatase (AP) in a similar way to, but more extensively and intensely than, the gonads of normal rams, and the staining was confined to interstitial cell\u2010like structures. The staining in the undifferentiated\u2010type freemartins was weak, but both 3\u03b2\u2010HSD and AP were present in unidentified cell types.<\/jats:p>","DOI":"10.1136\/vr.152.6.164","type":"journal-article","created":{"date-parts":[[2010,10,8]],"date-time":"2010-10-08T13:44:05Z","timestamp":1286545445000},"page":"164-169","source":"Crossref","is-referenced-by-count":10,"title":["Morphological, histological and histochemical studies of the gonads of ovine freemartins"],"prefix":"10.1002","volume":"152","author":[{"given":"K. C.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Clinical Veterinary Science University of Bristol Langford House, Langford Bristol BS40 5DU"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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E.","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Clinical Veterinary Science University of Bristol Langford House, Langford Bristol BS40 5DU"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,2,7]]},"reference":[{"volume-title":"Developments in Steroid Histochemistry","year":"1966","author":"BAILLIE A. H.","key":"e_1_2_6_2_1"},{"key":"e_1_2_6_3_1","first-page":"108","article-title":"Freemartins in booroola merino populations","volume":"17","author":"BINDON B. M.","year":"1985","journal-title":"Proceedings of the Australian Society of Reproductive Biology"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)34579-X"},{"key":"e_1_2_6_5_1","first-page":"919","article-title":"Frequence du freemartinism des agnelles booroola merinos d'Arles","volume":"16","author":"CRIBIU E. 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